Results 161 to 170 of about 269,189 (237)

Catalyst-Free Cyclization- and Curtius Rearrangement-Induced Functional Group Transformation: An Improved Synthetic Strategy of First-in-Class ATX Inhibitor Ziritaxestat (GLPG-1690)

Organic Process Research and Development, 2020
A practical and highly efficient protocol for the production of Autotaxin (ATX) inhibitor Ziritaxestat (1) was described.
Yu Yang, Nan Jiang, Ping Gong
exaly   +2 more sources

Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

Green Chemistry, 2017
Maurice A Marsini, Frank Roschangar
exaly   +2 more sources

Some Applications of the Curtius Rearrangement

Journal of the Chemical Society, Perkin Transactions 1, 1983
Pairs of optically pure enantiomers of substituted 1,1 -diamines have been prepared from the azides of L-amino-acids via the Curtius rearrangement.This synthesis is based on the interchange of two groups attached to the asymmetrically substituted tetrahedral α-carbon atom of the parent amino acid.
Iphigenia Photaki, Panagiota Moutevelis-Minakakis   +1 more
openaire   +2 more sources

Synthesis of 2,2‐[60]Fullerenoalkylamines (IV) via the Curtius Rearrangement. [PDF]

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kazuhiko Saigo, Yasuhiro Ishida, Tomoyuki Tada   +2 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of 2‐Arylethylamines by the Curtius Rearrangement. [PDF]

ChemInform, 2010
AbstractNovel chemical syntheses of amphetamines (V), (VIII) and (XV) as well as wescaline (XI) using the Curtius rearrangement as key reaction are developed.
openaire   +2 more sources

Improved Preparation of Tyramine by Curtius Rearrangement

Chinese Journal of Chemistry, 2009
AbstractAn improved and facile preparation of tyramine [2‐(p‐hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β‐(p‐hydroxyphenyl) propionic acid via Friedel‐Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield.
Li-Xin Wang, Shiyin Pan, Xiaoying Xu, Fan Yang, Chuanqin Xia, Yun Li   +5 more
openaire   +3 more sources

An Improved Synthesis of Urea Derivatives from N-Acylbenzotriazole via Curtius Rearrangement

Synthesis, 2019
The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N-acyl, and cyclic ureas in good yields from N-acylbenzotriazoles by treating the latter with various amines in the presence of TMSN3 ...
Vinod K Tiwari
exaly   +2 more sources

Curtius-type rearrangement of a sulphonyl azide

Journal of the Chemical Society D: Chemical Communications, 1969
Six products have been identified from the thermolysis of mesitylene-2-sulphonyl azide in dodecane: two are derived from a Curtius-type rearrangement of the corresponding sulphonyl nitrene.
Rudolph A. Abramovitch, W. D. Holcomb
openaire   +2 more sources

ChemInform Abstract: The Use of Curtius Rearrangement in the Synthesis of 4‐Aminothiazolidines.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Edson R. Costenaro, Mara Elisa Fortes Braibante, Hugo T. S. Braibante   +2 more
openaire   +3 more sources

ChemInform Abstract: Synthesis of (‐)‐Oseltamivir by Using a Microreactor in the Curtius Rearrangement.

ChemInform, 2011
AbstractThe method avoids the isolation of the potentially hazardous azide intermediate and can be scaled up as an industrial process.
Bojan P. Bondzic, Hayato Ishikawa, Hayato Ishikawa, Yujiro Hayashi   +3 more
openaire   +3 more sources