Results 21 to 30 of about 8,110 (222)
Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging [PDF]
, 2021 The use of continuous flow as an enabling technology within the fine chemical and pharmaceutical industries continues to gain momentum. The associated safety benefits with flow for handling of hazardous or highly reactive intermediates are often ...
Baumann, Marcus +4 more
core +2 more sources
Distribution of atomic rearrangement vectors in a metallic glass [PDF]
Journal of Applied Physics 132, 195103 (2022), 2022 Short-timescale atomic rearrangements are fundamental to the kinetics of glasses and frequently dominated by one atom moving significantly (a rearrangement), while others relax only modestly. The rates and directions of such rearrangements (or hops) are dominated by the distributions of activation barriers (Eact) for rearrangement for a single atom and
arxiv +1 more source
Журнал органічної та фармацевтичної хімії, 2023 Poly(ADP-ribose) polymerases (PARPs) are key enzymes in the DNA repair pathway. Inhibitors of these enzymes belong to a new type of anticancer drugs that selectively kill cancer cells by targeting the homologous recombination genetic defects.
Oleh O. Lukianov +4 more
doaj +1 more source
3,3-dichloro-1,2-diphenylcyclopropene (CPICl)-mediated synthesis of Nα-protected amino acid azides and α-ureidopeptides [PDF]
, 2014 Rapid synthesis of acid azides via in situ generation of acid chlorides using CPICl as chlorinating agent from the corresponding Nα -protected amino acids is described.
Madhu, C. +3 more
core +4 more sources
Журнал органічної та фармацевтичної хімії, 2023 Aim. To synthesize cyclobutane-derived amines and carboxylic acids bearing CH2F or CHF2 groups in the α position; to determine the regularities of the effect of fluoroalkyl substituents on the acid-base properties of the title compounds.
Oleksandr Demchuk, Oleksandr Grygorenko
doaj +1 more source
Convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines
Журнал органічної та фармацевтичної хімії, 2021 Aim. To develop convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines as promising biologically active scaffolds. Results and discussion.
Georgiy G. Yakovenko, Mikhailo V. Vovk
doaj +1 more source
The preparative synthetic approach to α,α-difluoro-γ-aminobutyric acid
Журнал органічної та фармацевтичної хімії, 2020 Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion.
Maksym Ya. Bugera +3 more
doaj +1 more source
Efficient Synthesis of O-Succinimidyl-(tert-Butoxycarbonylamino)methyl Carbamates Derived from α-Amino Acids Accelerated by Ultrasound: Application to the Synthesis of Ureidodipeptides [PDF]
, 2008 The synthesis of O-succinimidyl-(tert-butoxycarbonylamino)methyl carbamates employing isocyanates made through the Curtius rearrangement of Boc-amino acid azides in the presence of N-hydroxysuccinimide under the influence of ultrasound is ...
Kantharaju, . +2 more
core +1 more source
Ureido Derivatives of Neoabietic Acid
Molbank, 2018 A series of ureido derivatives of neoabietic acid were synthesized by application of Curtius rearrangement reaction to neoabietic acid and amines. Structure characterization of these compounds was done by 1H-NMR, 13C-NMR and HRMS spectral analysis.
Xinyu Gao +4 more
doaj +1 more source
Reactive & Efficient: Organic Azides as Cross-Linkers in Material Sciences
Molecules, 2020 The exceptional reactivity of the azide group makes organic azides a highly versatile family of compounds in chemistry and the material sciences. One of the most prominent reactions employing organic azides is the regioselective copper(I)-catalyzed ...
Marvin Schock, Stefan Bräse
doaj +1 more source