Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)-and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. [PDF]
, 1999 Various approaches to the synthesis of all four stereoisomers of 2-(1H- imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported.
Appelberg, U. +11 more
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Thermally activated foaming compositions Patent [PDF]
, 1969 Storage stable, thermally activated foaming compositions for erecting and rigidizing mechanisms of thin sheet solar ...
Welling, C. E.
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Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]
, 2013 The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E. +42 more
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Crystal structure of tert-butyl 2-phenylethylcarbamate, C13H19NO2 [PDF]
, 2016 C13H19NO2, monoclinic, P21/n (no. 14), a = 5.2692(3) Å, b = 13.8663(9) Å, c = 17.8020(13) Å, β = 93.323(6)°, V = 1298.50(15), Z = 4, R gt(F) = 0.0590, wR ref(F 2) = 0.1932, T = 293 K.
Ajarim, Mansour D. +4 more
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Redefining the Scope of the Curtius Reaction via a Dehomologation of Carboxylic Acids Bearing an Alpha Leaving Group. Determining the Stereoelectronic Limitations of the Crimmins Anti-selective Asymmetric Glycolate Aldol Addition Reaction. [PDF]
The Curtius rearrangement is an important synthetic transformation in organic chemistry and is named in honor of Theodore Curtius who developed this reaction in the late 19th century.
Odeh, Joy
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Lossen Rearrangement Reaction of Aromatic and Aliphatic Hydroxamates [PDF]
, 2016 The main goal of this research is to explore a potential of the most green and non-toxic possible route to the synthesis of industrially important chemicals, such as isocyanates and amines, based on the bio-based starting materials.
Sanaallah, Mirvat
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The Synthesis and Characterization of the 2,2\u27-Bisacylazide of 3,3\u27-Bipyridine [PDF]
, 1972 The primary objective of this research has been the synthesis and characterization of a new heterocyclic diacylazide, the 2,2\u27-bisacylazide of 3,3\u27-bipyridine 19.
El-Fayoumy, Magdy Adly Guirguis
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Synthesis of Ureido-Linked Glycosylated Amino Acids from N α-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis [PDF]
, 2008 A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from N α-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis.
Sureshbabu, V.V., Venkataramanarao, R.
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An alternative approach to aminodiols from Baylis-Hillman adducts: stereoselective synthesis of chloramphenicol, fluoramphenicol and thiamphenicol [PDF]
, 2015 We describe herein a new approach for the stereoselective synthesis of broad spectrum antibiotics from Baylis-Hillman adducts. The strategy is based on the preparation of an ene-carbamate directly from a Baylis-Hillman adduct using a Curtius ...
Coelho, Fernando, Mateus, Cristiano R.
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Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]
, 2019 A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H. +2 more
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