Results 51 to 60 of about 266,703 (209)

Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)-and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. [PDF]

open access: yes, 1999
Various approaches to the synthesis of all four stereoisomers of 2-(1H- imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported.
Appelberg, U.   +11 more
core   +6 more sources

Thermally activated foaming compositions Patent [PDF]

open access: yes, 1969
Storage stable, thermally activated foaming compositions for erecting and rigidizing mechanisms of thin sheet solar ...
Welling, C. E.
core   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

open access: yes, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E.   +42 more
core   +1 more source

Crystal structure of tert-butyl 2-phenylethylcarbamate, C13H19NO2 [PDF]

open access: yes, 2016
C13H19NO2, monoclinic, P21/n (no. 14), a = 5.2692(3) Å, b = 13.8663(9) Å, c = 17.8020(13) Å, β = 93.323(6)°, V = 1298.50(15), Z = 4, R gt(F) = 0.0590, wR ref(F 2) = 0.1932, T = 293 K.
Ajarim, Mansour D.   +4 more
core   +1 more source

Redefining the Scope of the Curtius Reaction via a Dehomologation of Carboxylic Acids Bearing an Alpha Leaving Group. Determining the Stereoelectronic Limitations of the Crimmins Anti-selective Asymmetric Glycolate Aldol Addition Reaction. [PDF]

open access: yes
The Curtius rearrangement is an important synthetic transformation in organic chemistry and is named in honor of Theodore Curtius who developed this reaction in the late 19th century.
Odeh, Joy
core   +2 more sources

Lossen Rearrangement Reaction of Aromatic and Aliphatic Hydroxamates [PDF]

open access: yes, 2016
The main goal of this research is to explore a potential of the most green and non-toxic possible route to the synthesis of industrially important chemicals, such as isocyanates and amines, based on the bio-based starting materials.
Sanaallah, Mirvat
core   +2 more sources

The Synthesis and Characterization of the 2,2\u27-Bisacylazide of 3,3\u27-Bipyridine [PDF]

open access: yes, 1972
The primary objective of this research has been the synthesis and characterization of a new heterocyclic diacylazide, the 2,2\u27-bisacylazide of 3,3\u27-bipyridine 19.
El-Fayoumy, Magdy Adly Guirguis
core   +1 more source

Synthesis of Ureido-Linked Glycosylated Amino Acids from N α-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis [PDF]

open access: yes, 2008
A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from N α-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis.
Sureshbabu, V.V., Venkataramanarao, R.
core   +1 more source

An alternative approach to aminodiols from Baylis-Hillman adducts: stereoselective synthesis of chloramphenicol, fluoramphenicol and thiamphenicol [PDF]

open access: yes, 2015
We describe herein a new approach for the stereoselective synthesis of broad spectrum antibiotics from Baylis-Hillman adducts. The strategy is based on the preparation of an ene-carbamate directly from a Baylis-Hillman adduct using a Curtius ...
Coelho, Fernando, Mateus, Cristiano R.
core   +1 more source

Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]

open access: yes, 2019
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H.   +2 more
core  

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