Results 71 to 80 of about 272,115 (235)
SmI2‐Catalyzed Coupling of Alkyl Housane Ketones and Alkenes in an Approach to Norbornanes
Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.Samarium diiodide (Sml2) is an effective catalyst for the mild, atom‐economical coupling of bicyclo[2.1.0]pentane, or housane, ketones, and electron‐deficient alkenes to give functionalized norbornane structural motifs not easily accessible by classical cycloaddition approaches.
Debayan Roy +7 more
wiley +1 more source
AgronomyThe exploitation of natural products as lead compounds continues to serve as a vital strategy for the discovery of novel fungicidal agents. This work designed and synthesized a series of carbamate derivatives based on the natural product physostigmine ...
Xiyao Liu +8 more
doaj +1 more source
A novel method for the synthesis of 1-aryltetrahydroisoquinolines [PDF]
, 2017 Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolecular trapping by pendant sulfonamide groups to provide excellent yields of 1 ...
Abdel-Fattah, Hanan A. +5 more
core +2 more sources
Hydrogen Peroxide‐Responsive Aminoferrocene Prodrugs
European Journal of Organic Chemistry, Volume 28, Issue 33, September 20, 2025.To improve sensitivity toward H2O2, the boronic acid pinacol ester in known aminoferrocene‐based anticancer prodrug 13b is replaced with an α‐ketamide fragment to obtain prodrug 2a and some of its N‐alkylated derivatives. 2a exhibits substantially improved cytotoxicity in vitro toward ovarian cancer A2780 and Burkitt's lymphoma BL‐2 cells.
Marlies Körber +3 more
wiley +1 more source
Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A) [PDF]
, 2017 We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or p- substitution of the aryl ring were micromolar inhibitors of the LSD1 enzyme.
Al-Jamal, Wafa T. +10 more
core +2 more sources
The Dihydroindeno[2,1‐c]fluorene Core: From Syntheses to Properties and Potential Applications
European Journal of Organic Chemistry, Volume 28, Issue 32, August 28, 2025.In this review, the latest research progress in synthesis and application of variously decorated aromatic compounds possessing the indeno[2.1‐c]fluorene scaffold is summarized. In addition to covering synthetic endeavors, their transformation to other structurally related aromatic compounds and their physical properties and possible applications are ...
Timothée Cadart, Martin Kotora
wiley +1 more source
Synthesis of retro-inverso peptides employing isocyanates of Nα-Fmoc-amino acids/peptide acids catalyzed by DMAP [PDF]
, 2006 The Goldschmidt-Wick type reaction between isocyanates of Nα-Fmoc-amino acids/peptide acids and Nα-Boc-/Z-/Bsmoc-amino acids catalyzed by DMAP leads to the incorporation of a reversed peptide bond.
Sureshbabu, V.V., Venkataramanarao, R.
core +1 more source
Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors
ChemPlusChem, Volume 90, Issue 8, August 2025.A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou +4 more
wiley +1 more source
Radical-mediated ring contraction in the biosynthesis of 7-deazapurines [PDF]
, 2015 Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction ...
Bandarian, Vahe, Drennan, Catherine L.
core +1 more source
Advances in Mechanochemical C─H Functionalization: A Comparative Study with Solvent‐Based Approaches
ChemCatChem, Volume 17, Issue 13, July 8, 2025.This review presents the latest advancements made in mechanochemical transition metal catalyzed C─H functionalization, comparing its efficiency, sustainability and scope with traditional solvent‐based methods. By offering a side‐by‐side comparison, it equips organic chemists with the insights needed to select the most effective approach for ...
Nanditha Kattukudiyil Narayanan +1 more
wiley +1 more source