Results 81 to 90 of about 504,478 (360)

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

A study on in-depth perception of customer behavior in digital business halls based on multimodal data integration

Discover Applied Sciences
To solve the problem of ineffective extraction of advanced features that reflect the essence of customer behavior and enhance customer stickiness.
Wei Cui, Bo Chen, Wei Ge
doaj   +1 more source

The Application of Article 85 of the EEC Treaty to Exclusive Distribution Agreements [PDF]

, 1984
Compares the application of EEC competition laws and U.S. antitrust laws to exclusive distribution agreements, and noting an interesting development in the two systems. Article analyzes Continental T.V., Inc. v. GTE Sylvania Inc.
Schroter, Helmuth R.B.
core   +1 more source

Reducing the delivery lead time in a food distribution SME through the implementation of six sigma methodology [PDF]

, 2009
Purpose – Six sigma is a systematic data driven approach to reduce the defect and improve the quality in any type of business. The purpose of this paper is to present the findings from the application of six sigma in a food service “small to medium sized
Nabhani, Farhad, Shokri, Alireza
core   +2 more sources

3D‐Printed Ion‐Conductive Hydrogels with Tunable Mechanical–Electrical Properties for Multimodal Sign Language Recognition

Advanced Science, EarlyView.
This work successfully fabricated ion‐conductive hydrogels with low hysteresis and high conductivity using 3D printing technology. By adjusting the component ratios, the properties of the hydrogels can be tuned to meet diverse sensing requirements. Finally, a multimodal sensing sign language recognition system was constructed based on this hydrogel ...
Quan Hu, Longya Xiao, Peiqi Zhang, Qiurui Zhang, Guangsen Liu, Xinglin Qin, Zhuhui Yin, Xian Li, Yuling Wang, Hongjie Jiang   +9 more
wiley   +1 more source

Supply chain integration as the implementation of strategic management in improving business performance

Discover Sustainability
This study explores how supply chain integration (SCI)—encompassing internal, supplier, and customer integration—enhances operational and financial performance.
Umari Abdurrahim Abi Anwar, Agus Rahayu, Lili Adi Wibowo, Mokh Adib Sultan, Tasya Aspiranti, Chairul Furqon, Asni Mustika Rani   +6 more
doaj   +1 more source

Orchestration of the Marketing Strategy under Competitive Dynamics [PDF]

Constructing suitable marketing strategy and implementing it effectively is an art and science both like orchestration of a symphony. The discussion in this paper blends this analogy with the science of marketing demonstrating the levels of strategy ...
Rajagopal
core  

Dispersive Full‐Channel Jones Matrix Modulation in Elliptical Polarization Bases via a Single‐Layered Metasurface

Advanced Science, EarlyView.
This work presents a dispersive full‐channel Jones matrix modulation strategy using single‐layer metasurface. By synergizing wavelength dispersion engineering with elliptical polarization bases, independent control of four Jones matrix channels is achieved across multiple wavelengths.
Hairong He, Guangtao Cao, Shuhao Zhang, Hui Xu, Zhiquan Chen, Meiyu Peng, Yuting Jiang, Yueqiang Hu, Hui Jing, Huigao Duan, Hui Yang   +10 more
wiley   +1 more source

Vertical Integration, Innovation and Foreclosure [PDF]

This paper studies the potential effects of vertical integration on downstream firms' incentives to innovate. Interacting efficiently with a supplier may require information exchanges, which raises the concern that sensitive information may be disclosed ...
Claire Chambolle, Marie-Laure Allain, Patrick Rey   +2 more
core  

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source