Results 181 to 190 of about 110,531 (202)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma. [PDF]

Elife
Bayanjargal A, Taslim C, Showpnil IA, Selich-Anderson J, Crow JC, Zhou R, Lessnick SL, Theisen ER.   +7 more
europepmc   +1 more source

Correction: PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression. [PDF]

Sci Rep
Teye EK, Lu S, Chen F, Yang W, Abraham T, Stairs DB, Wang HG, Yochum GS, Brodsky RA, Pu JJ.   +9 more
europepmc   +1 more source

Epigenetic analysis of sheep mycoplasma pneumonia and the effect of <i>FOXF1</i> on <i>Mycoplasma ovipneumoniae</i> infection. [PDF]

Virulence
Huang K, Cheng J, Lu Q, Peng J, Han K, Zhang X, Yuan L, Tian H, Li F, Wang W.   +9 more
europepmc   +1 more source

ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A. [PDF]

Stem Cell Reports
Valceschini E, Gomez Ramos B, Ohnmacht J, Ginolhac A, Catillon M, Gerard D, Gaigneaux A, Kyriakis D, Grzyb K, Glaab E, Grünewald A, Skupin A, Sauter T, Krüger R, Sinkkonen L.   +14 more
europepmc   +1 more source

Mapping Histone post-translational modifications in the Pacific oyster using iDeal CUT&Tag and the Tissue Nuclei Extraction Module [PDF]

Dellong, Amélie, Allienne, Jean-françois, Chaparro, Cristian, Vidal Dupiol, Jeremie, Clément, Julie, Cosseau, Céline, Zelisko-schmidt, Agnieszka, Apulei, Jessica, Grunau, Christophe   +8 more
openaire  

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Cut, Tagged, and Sent Off

Science Signaling, 2000
Activation of a set of proteases known as caspases is an important part of the cellular signaling mechanisms that lead to cell death or apoptosis. One caspase target is the protein BID, which, after cleavage, translocates from the cytosol to the mitochondrial membrane.
  +4 more sources

The protocol of CUT&Tag for metabolic tissue cells.

Yi chuan = Hereditas, 2022
Cleavage under target and tagment (CUT&Tag) is a technology that utilizes the fusion protein of Tn5 transposase and protein A/G which can guide Tn5 enzyme to the antibody bound to target protein and cleave the chromatin regions adjacent to target protein.
Zi-Yin, Zhang, Yan-Ping, Zhou, Zhuo-Xian, Meng   +2 more
openaire   +1 more source