Results 31 to 40 of about 134,257 (306)

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

Insulin Resistance as a Risk Factor for Cutaneous Melanoma. A Case Control Study and Risk-Assessment Nomograms

Frontiers in Endocrinology, 2019
Insulin resistance and obesity are suggested to have a key role in the molecular pathogenesis of various disorders, including several malignancies. Moreover, insulin resistance has recently been found to be associated with cutaneous and uveal melanoma ...
Alessandro Scoppola, Lidia Strigari, Agnese Barnabei, Pierpaolo Petasecca, Federica De Galitiis, Claudia Angela Maria Fulgenzi, Mario Roselli, Antonino De Lorenzo, Laura Di Renzo, Paolo Marchetti, Paolo Marchetti, Francesco Torino   +11 more
doaj   +1 more source

Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]

, 2018
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski, Anna Brożyna, Anna Markiewicz, Bożena Romanowska-Dixon, Ewa Podgórska, Krystyna Urbańska, Martyna Elas, Martyna Śniegocka, Małgorzata Szczygieł, Michał Żmijewski, Mirosława Cichorek, Przemysław Płonka   +11 more
core   +1 more source

The clinical and histopathological features of patients with both uveal and cutaneous melanoma

The Pan-American Journal of Ophthalmology, 2020
Introduction: It is unusual to have uveal and cutaneous melanoma in the same patient. It is challenging to differentiate between primary uveal melanoma (UM) and melanoma metastatic to the uvea.
Anelise Savaris Dias, Julia Valdemarin Burnier, Sabrina Bergeron, Denise Miyamoto, Paulo César de Campos Ferreira, Carolina Nishiwaki Dantas, Jacqueline Coblentz, Miguel Noel Burnier   +7 more
doaj   +1 more source

Functional Prediction of Long Noncoding RNAs in Cutaneous Melanoma Using a Systems Biology Approach

Bioinformatics and Biology Insights, 2021
Cutaneous melanoma is the most aggressive type of skin cancer which its incidence has significantly increased in recent years worldwide. Thus, more investigations are required to identify the underlying mechanisms of melanoma malignant transformation and
Mozhdeh Shahmoradi, Zahra Rezvani
doaj   +1 more source

The Outcome of Patients with Melanoma Is Not Associated with the Time Point of Lymphatic Mapping with Respect to Excisional Biopsy of the Primary Tumor [PDF]

, 2010
Background: Sentinel lymph node biopsy (SLNB) has become the standard care for melanoma and is an important diagnostic procedure. It has been doubted whether lymphoscintigraphy detects the correct sentinel lymph node (SLN) when excision of the tumor and ...
Baumert, Jens, Berking, Carola, Flaig, Michael J., Gauwerky, Katharina J., Geimer, Till, Kunte, Christian, Ruzicka, Thomas, Schmid-Wendtner, Monika-Hildegard   +7 more
core   +1 more source

Cutaneous melanoma in women

International Journal of Women's Dermatology, 2015
Gender disparity in melanoma outcome is consistently observed, suggesting that gender is as an important prognostic factor. However, the source of this gender disparity in melanoma remains unclear.This article reviews advances in our understanding of gender differences in melanoma and how such differences may contribute to outcomes.A broad literature ...
Roh, Mi Ryung, Eliades, Philip, Grant-Kels, Jane M., Gupta, Sameer, Tsao, Hensin   +4 more
openaire   +7 more sources

Clinicopathological features and pituitary homeobox 1 gene expression in the progression and prognosis of cutaneous malignant melanoma

Kaohsiung Journal of Medical Sciences, 2016
The evidence that PITX1 (pituitary homeobox 1) is a significant tumor suppressor in human cancer remains largely circumstantial, but it clearly warrants further study as little is known about the tumor-inhibitory roles of PITX1 in cutaneous malignant ...
Figen Barut, Perihan Udul, Furuzan Kokturk, Nilufer Onak Kandemir, Sevinc Hallac Keser, Sukru Oguz Ozdamar   +5 more
doaj   +1 more source

Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma. [PDF]

PLoS ONE, 2011
Cutaneous melanoma is a lethal malignancy that arises spontaneously or via in situ precursor neoplasms. While melanoma in situ and locally invasive malignant melanoma can be cured surgically, these lesions can sometimes be difficult to distinguish from ...
Jinah Kim, Salma Dabiri, E Scott Seeley
doaj   +1 more source

Cutaneous malignant melanoma in skin of color individuals

Nigerian Journal of Medicine, 2021
Cutaneous malignant melanoma (CMM) is a malignancy with a worldwide incidence. Literature is replete in the Caucasian population, but in skin of color, there is a dearth of literature. Documented reports of the epidemiology of cutaneous melanoma reveal a
Ehiaghe Lonia Anaba
doaj   +1 more source