Results 61 to 70 of about 3,517,652 (393)
Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]
, 2011 The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Baili, Maher +3 more
core +3 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesUnderstanding the distribution of cutting force provides a foundation for the design and optimization of cutterhead layout. The simulation of rotary cutting with a large cutting radius remains a challenge for laboratory tests.
Long-Chuan Deng +6 more
doaj +1 more source
Research into mechanical modeling based on characteristics of the fracture mechanics of ice cutting for scientific drilling in polar regions [PDF]
The CryosphereScientific drilling in polar regions plays a crucial role in obtaining ice cores and using them to understand climate change and to study the dynamics of polar ice sheets and their impact on global environmental changes (sea level, ocean current cycle ...
X. Lv +8 more
doaj +1 more source
Experimental and numerical study of laser-assisted machining of Ti6Al4V titanium alloy [PDF]
, 2014 Laser-assisted machining combines several experimental parameters such as cutting speed, feed rate, depth of cut, laser power and distance between tool rake face and the laser beam axis.
AYED, Yessine +3 more
core +6 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cutting Force Prediction in Drilling of Titanium Alloy
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA +2 more
doaj +1 more source
Hip External Rotator Strength Is Associated With Better Dynamic Control of the Lower Extremity During Landing Tasks [PDF]
, 2016 Hip external rotator strength is associated with better dynamic control of the lower extremity during landing tasks. J Strength Cond Res 30(1): 282–291, 2016—The purpose of this study was to determine the association between hip strength and lower ...
Geiser, Christopher +4 more
core +2 more sources
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source