Results 61 to 70 of about 89,685 (265)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Size Effect in Metal Cutting Force
Journal of the Japan Society of Precision Engineering, 1965 The theoretical consideration of energies consumed in metal cutting and the experimental observations on orthogonal light cutting of 4-6 brass lead to the conclusion that the size effect in cutting force can be explained as follows: with the decrease in depth of cut, the specific cutting force increases because of(1) decrease in magnitude of shear ...
K. Tamura, K. Nakayama
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Slicing Cuts on Food Materials Using Robotic-Controlled Razor Blade
Modelling and Simulation in Engineering, 2011 Cutting operations using blades can arise in a number of industries, for example, food processing industry, in which cheese, fruit and vegetable, even meat, are involved.
Debao Zhou, Gary McMurray
doaj +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019 To improve machining efficiency, it is necessary to know the machining status and optimize cutting conditions. Cutting force prediction is one method of determining the machining status.
Kazuki KANEKO +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1987 As the cutting condition of generating gears such as in hobbing is very complex, the specific cutting forces are different from those of orthogonal turning. In general, the specific cutting forces in hobbing are large, since the flowing chips interfere on the tool face.
Toshio SUZUKI +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Simulation analysis of shearer drum cutting coal-rock under oblique cutting conditio
Gong-kuang zidonghua, 2018 In order to study movement rule and force characteristic of shearer drum under oblique cutting condition, virtual prototype model of shearer under oblique cutting condition was established by use of ADAMS, and movement curve of shearer drum was obtained ...
YUAN Bin, WANG Yiliang, YANG Zhaojian
doaj +1 more source