Results 71 to 80 of about 927,555 (356)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Cutting Force and Cutting Quality during Tapered Milling of Glass Magnesium Board
Applied Sciences, 2019 In this paper, the effects of tool geometry and cutting parameters on cutting force and quality were investigated during the tapered milling of glass magnesium (MGO) board with diamond cutters. The results were as follows: firstly, both the cutting force
Pingxiang Cao +5 more
doaj +1 more source
Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]
, 2014 The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain +3 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Metal: Jurnal Sistem Mekanik dan Termal, 2020 Milling machine is a machine that cuts a workpiece using a plural chisel that rotates on a freis machine. During the freis process, the material is cut because of the cutting force that occurs between the tool and the workpiece.
Firman Ridwan, Refki Harvendri
doaj +1 more source
Research on abrasive wear dress of CBN honing tool based on single abrasive cutting
Jin'gangshi yu moliao moju gongcheng, 2022 The abrasive wear characteristics of large length to diameter ratio CBN single-pass honing tools during ultrasonic dressing process were studied by single abrasive test with 4Cr13 stainless steel as dressing material.
Changyong YANG +3 more
doaj +1 more source
On the effect of distributed regenerative delay on the stability lobe diagrams of milling processes [PDF]
, 2015 Regenerative machine tool chatter is investigated for milling operations with helical tools. The stability of a two-degrees-of-freedom milling model is analyzed, where the cutting-force is modeled as a force system distributed along the rake face of the ...
Insperger, Tamás +1 more
core +3 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Force-frequency effect of Y-cut langanite and Y-cut langatate [PDF]
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2003 Most recently, langasite and its isomorphs (LGX) have been advanced as potential substitutes for quartz, owing to their extremely high-quality (Q) factors. At least twice higher Q value of LGX than that of quartz has been reported. High Q translates into potentially greater stability.
Yoonkee, Kim, Arthur, Ballato
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source