Results 81 to 90 of about 3,517,652 (393)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Perancangan Dinamometer untuk Mengukur Gaya Potong pada Mesin Freis untuk Pemesinan Material Fiber Reinforced Polymer

open access: yesMetal: Jurnal Sistem Mekanik dan Termal, 2020
Milling machine is a machine that cuts a workpiece using a plural chisel that rotates on a freis machine. During the freis process, the material is cut because of the cutting force that occurs between the tool and the workpiece.
Firman Ridwan, Refki Harvendri
doaj   +1 more source

Development of an in-house cutting forces simulation for fir tree broaching process [PDF]

open access: yes, 2014
This article proposes a simulation of cutting forces in broaching of fir tree slots. Every step needed to build an in-house fir tree broaching simulation is presented.
Cazenave-Larroche, Gilles   +5 more
core   +2 more sources

Frequency and Time-Frequency Analysis of Cutting Force and Vibration Signals for Tool Condition Monitoring

open access: yesIEEE Access, 2018
Tool condition monitoring systems are essential in micromilling applications. A tool’s slenderness requires high-precision monitoring systems for online measurements.
J. Jauregui   +5 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Pengaruh Variasi Parameter Proses Pemesinan Terhadap Gaya Potong Pada Mesin Bubut Knuth Dm-1000a [PDF]

open access: yes, 2015
This research was aimed at knowing the cutting force a lathe with several parameters: rotation condition,varied cutting depth,and constant eater motion.
Hindom, S. D. (Stella)   +2 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen   +11 more
wiley   +1 more source

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