Results 1 to 10 of about 354 (118)

Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine [PDF]

mSphere
Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes fatal T cell lymphomas in chickens. Oncogenic MDV strains can integrate their genome into the host telomeres of latently infected and tumor cells.
Luca D. Bertzbach, Yu You, Tereza Vychodil, Ahmed Kheimar, Lisa Kossak, Mohammad A. Sabsabi, Andelé M. Conradie, Benedikt B. Kaufer   +7 more
doaj   +4 more sources

V5 and GFP Tagging of Viral Gene pp38 of Marek’s Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing [PDF]

Viruses, 2022
Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. The availability of the complete sequence of the viral genome allowed for the identification of major genes
Weicheng Li, Yaoyao Zhang, Katy Moffat, Venugopal Nair, Yongxiu Yao   +4 more
doaj   +4 more sources

Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus [PDF]

Viruses
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence.
Jumpei Sato, Yoshinosuke Motai, Shunsuke Yamagami, Aoi Kurokawa, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +11 more
doaj   +4 more sources

A quadruplex real-time PCR assay combined with a conventional PCR for the differential detection of Marek’s disease virus vaccines and field strains [PDF]

Frontiers in Veterinary Science, 2023
To evaluate the effect of the vaccine and differentiate vaccine from virulent MDV, a new quadruplex real-time PCR assay based on TaqMan probes was developed to differentiate and accurately quantify HVT, CVI988 and virulent MDV-1.
Shaopeng Wu, Shaopeng Wu, Shaopeng Wu, Tian Ding, Tian Ding, Tian Ding, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +17 more
doaj   +2 more sources

A novel protein-coding ORF72.2 gene was identified from Marek's disease virus strain CVI988 [PDF]

Virology Journal, 2010
Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear.
Liu Ping, Zou Nianli, Lin Yan, Shi Min, Zhao Yang, Tian Mingxing, Wen Xintian, Cao Sanjie, Huang Yong   +8 more
doaj   +3 more sources

Differential Replication and Cytokine Response between Vaccine and Very Virulent Marek’s Disease Viruses in Spleens and Bursas during Latency and Reactivation [PDF]

Viruses, 2022
Marek’s disease virus (MDV) infection results in Marek’s disease (MD) in chickens, a lymphoproliferative and oncogenic deadly disease, leading to severe economic losses. The spleen and bursa are the most important lymphoid and major target organs for MDV
Bo Jiang, Jing Wang, Mengyao Cao, Huan Jin, Wenxiao Liu, Jing Cheng, Linyi Zhou, Jian Xu, Yongqing Li   +8 more
doaj   +2 more sources

Real-time PCR for differential quantification of CVI988 vaccine virus and virulent strains of Marek’s disease virus

Journal of Virological Methods, 2016
CVI988/Rispens vaccine, the 'gold standard' vaccine against Marek's disease in poultry, is not easily distinguishable from virulent strains of Marek's disease herpesvirus (MDV). Accurate differential measurement of CVI988 and virulent MDV is commercially important to confirm successful vaccination, to diagnose Marek's disease, and to investigate causes
Venugopal Nair
exaly   +3 more sources

Genomic analysis of a Chinese MDV strain derived from vaccine strain CVI988 through recombination

Infection, Genetics and Evolution, 2020
Disease caused by Marek's disease virus (MDV), a highly oncogenic alpha-herpesvirus, is controlled mainly by vaccination. Since 1990s, CVI988 has been widely used as vaccine strain. However, as an attenuated live vaccine, CVI988 has the potential of virulence enhancement and the risk of recombination that should be considered.
Yongchang Cao, Juo Luo
exaly   +3 more sources

An Anti-Tumor Vaccine Against Marek's Disease Virus Induces Differential Activation and Memory Response of γδ T Cells and CD8 T Cells in Chickens

Frontiers in Immunology, 2021
Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens.
Xiaoli Hao, Xiaoli Hao, Xiaoli Hao, Shuai Li, Jiaqi Li, Yi Yang, Yi Yang, Yi Yang, Aijian Qin, Aijian Qin, Aijian Qin, Aijian Qin, Shaobin Shang, Shaobin Shang, Shaobin Shang, Shaobin Shang   +15 more
doaj   +1 more source

Genetic evolution of Marek's disease virus in vaccinated poultry farms [PDF]

Veterinary World, 2021
Background and Aim: The Marek's disease virus (MDV) is a neoplastic disease causing serious economic losses in poultry production. This study aimed to investigate MDV occurrence in poultry flocks in the Lower Egypt during the 2020 breakout and ...
Nahed Yehia, Hemat S. El-Sayed, Sabry E. Omar, Ahmed Erfan, Fatma Amer   +4 more
doaj   +1 more source