Results 1 to 10 of about 518 (147)

Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine [PDF]

MSphere
Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes fatal T cell lymphomas in chickens. Oncogenic MDV strains can integrate their genome into the host telomeres of latently infected and tumor cells.
Ahmed Kheimar, Andelé M Conradie, Luca Bertzbach   +2 more
exaly   +8 more sources

Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus [PDF]

Viruses
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence.
Tomohiro Okagawa, Shiro Murata, Aoi Kurokawa   +2 more
exaly   +7 more sources

V5 and GFP Tagging of Viral Gene pp38 of Marek’s Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing [PDF]

Viruses, 2022
Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. The availability of the complete sequence of the viral genome allowed for the identification of major genes
Weicheng Li, Yaoyao Zhang, Katy Moffat, Venugopal Nair, Yongxiu Yao   +4 more
doaj   +6 more sources

Differential Replication and Cytokine Response between Vaccine and Very Virulent Marek’s Disease Viruses in Spleens and Bursas during Latency and Reactivation [PDF]

Viruses, 2022
Marek’s disease virus (MDV) infection results in Marek’s disease (MD) in chickens, a lymphoproliferative and oncogenic deadly disease, leading to severe economic losses. The spleen and bursa are the most important lymphoid and major target organs for MDV
Bo Jiang, Jing Wang, Mengyao Cao, Huan Jin, Wenxiao Liu, Jing Cheng, Linyi Zhou, Jian Xu, Yongqing Li   +8 more
doaj   +3 more sources

Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines [PDF]

Viruses, 2023
As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-Ling Liu, Man Teng, Lu-Ping Zheng, Feng-Xia Zhu, Shu-Xue Ma, Lin-Yan Li, Zhi-Hui Zhang, Shu-Jun Chai, Yongxiu Yao, Jun Luo   +9 more
doaj   +3 more sources

A quadruplex real-time PCR assay combined with a conventional PCR for the differential detection of Marek’s disease virus vaccines and field strains [PDF]

Frontiers in Veterinary Science, 2023
To evaluate the effect of the vaccine and differentiate vaccine from virulent MDV, a new quadruplex real-time PCR assay based on TaqMan probes was developed to differentiate and accurately quantify HVT, CVI988 and virulent MDV-1.
Shaopeng Wu, Shaopeng Wu, Shaopeng Wu, Tian Ding, Tian Ding, Tian Ding, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +17 more
doaj   +2 more sources

Epidemiology of Marek's Disease Virus Type 2 and the Molecular and Pathology Characterization of Virus Isolates in China (2015-2024). [PDF]

Transbound Emerg Dis
Marek’s disease (MD) continues to cause significant economic losses in the global poultry industry. During routine MD surveillance in China, MD virus type 2 (MDV‐2), which has the potential for widespread dissemination, was detected. In this study, 2842 suspected MD samples were collected from 237 poultry flocks vaccinated against MD across 21 ...
Lin Y, Hu M, Wu C, Lu H, Chen M, Liu C, Cui H, Liu Y, Qi X, Wang S, Chen Y, Duan Y, Gao Y, Zhang Y.   +13 more
europepmc   +2 more sources

The emergence of a highly pathogenic marek’s disease virus featuring newly identified mutations in Meq oncogene in Southern China [PDF]

Virology Journal
Background Marek’s disease virus (MDV) is a significant threat to global poultry health, causing high mortality, tumor formation, and severe immunosuppression, leading to substantial economic losses.
Qiong Luo, Huimin Li, Zengxu Ge, Zhanhong Chen, Ruiai Chen   +4 more
doaj   +2 more sources

A novel protein-coding ORF72.2 gene was identified from Marek's disease virus strain CVI988 [PDF]

Virology Journal, 2010
Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear.
Liu Ping, Zou Nianli, Lin Yan, Shi Min, Zhao Yang, Tian Mingxing, Wen Xintian, Cao Sanjie, Huang Yong   +8 more
doaj   +3 more sources

Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection [PDF]

Microbiology Spectrum, 2022
Marek’s disease virus (MDV) induces immunosuppression and neoplastic disease in chickens. The virus is controllable via an attenuated meq deletion mutant virus, which has the disadvantage of retaining the ability to induce lymphoid organ atrophy.
Aijun Sun, Xuyang Zhao, Xiaojing Zhu, Zhengjie Kong, Yifei Liao, Man Teng, Yongxiu Yao, Jun Luo, Venugopal Nair, Guoqing Zhuang, Gaiping Zhang   +10 more
doaj   +2 more sources