Role of the multiple telomeric repeat arrays in integration, persistence, and efficacy of the commercial CVI988 vaccine [PDF]
mSphereMarek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes fatal T cell lymphomas in chickens. Oncogenic MDV strains can integrate their genome into the host telomeres of latently infected and tumor cells.
Bertzbach, Luca D. +7 more
core +5 more sources
V5 and GFP Tagging of Viral Gene pp38 of Marek’s Disease Vaccine Strain CVI988 Using CRISPR/Cas9 Editing [PDF]
Viruses, 2022 Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. The availability of the complete sequence of the viral genome allowed for the identification of major genes associated with pathogenicity using different techniques, such as bacterial artificial chromosome ...
Weicheng Li +4 more
openaire +4 more sources
A novel protein-coding ORF72.2 gene was identified from Marek's disease virus strain CVI988 [PDF]
Virology Journal, 2010 Abstract Marek's disease is a highly contagious disease of poultry characterized by rapid-on set of T-cell lymphomas, which is caused by Marek's disease virus (MDV), but its pathogenic mechanism is still not very clear. Recently, some new progress were achieved in molecular character of MDV. Along with the genomic sequencing of MDV serotype 1,
Liu Ping +8 more
openaire +4 more sources
Journal of Virological Methods, 2016 CVI988/Rispens vaccine, the 'gold standard' vaccine against Marek's disease in poultry, is not easily distinguishable from virulent strains of Marek's disease herpesvirus (MDV). Accurate differential measurement of CVI988 and virulent MDV is commercially important to confirm successful vaccination, to diagnose Marek's disease, and to investigate causes
Venugopal Nair
exaly +3 more sources
Genomic analysis of a Chinese MDV strain derived from vaccine strain CVI988 through recombination
Infection, Genetics and Evolution, 2020 Disease caused by Marek's disease virus (MDV), a highly oncogenic alpha-herpesvirus, is controlled mainly by vaccination. Since 1990s, CVI988 has been widely used as vaccine strain. However, as an attenuated live vaccine, CVI988 has the potential of virulence enhancement and the risk of recombination that should be considered.
Jun Luo, Yongchang Cao
exaly +3 more sources
A Review on the Marek’s Disease Outbreak and Its Virulence-Related meq Genovariation in Asia between 2011 and 2021 [PDF]
Animals, 2022 Marek’s disease is an infectious disease in poultry that usually appears in neural and visceral tumors. This disease is caused by Gallid alphaherpesvirus 2 infection in lymphocytes, and its meq gene is commonly used in virulent studies for coding the key
Aziz M. U. +9 more
core +3 more sources
Isolation and analysis of a very virulent Marek’s disease virus strain in China [PDF]
, 2013 BACKGROUND: A severe MD was broken out at a farm in Shandong, China, despite FC126 vaccination of the chickens at 1-day-old. The mortality of the flocks reached up to 38.3%.
Hongchao Ma +6 more
core +4 more sources
Classification of Marek's disease viruses according to pathotype: Philosophy and methodology [PDF]
, 2019 El concepto de patotipo en la enfermedad de Marek (MD) data probablemente de finales de los 1950s cuando se reconoció una forma más virulenta de enfermedad Benton y Cover, 1957). Las distinciones entre las diferentes cepas de virus de MD (MDV) fueron aún
Buscaglia, Celina +4 more
core +6 more sources
Rapid, Sensitive, and Species-Specific Detection of Conventional and Recombinant Herpesvirus of Turkeys Vaccines Using Loop-Mediated Isothermal Amplification Coupled With a Lateral Flow Device Readout [PDF]
, 2022 Marek's disease, an economically important disease of chickens caused by virulent serotype 1 strains of the Mardivirus Marek's disease virus (MDV-1), is effectively controlled in the field by live attenuated vaccine viruses including herpesvirus of ...
Baigent, Susan J +3 more
core +1 more source
Novel genetic factors in Marek’s disease virus pathogenesis and establishment of a cell culture-based viral integration system [PDF]
, 2022 Marek’s disease virus (MDV) is a highly contagious alphaherpesvirus that causes neurological disorders, immunosuppression, and deadly lymphomas in chickens.
You, Yu
core +1 more source