The Development and Evaluation of an SYBR Green I-Based qPCR Assay for Detecting the Marek’s Disease Virus SC9-1 Vaccine Strain [PDF]
VirusesThe increasing virulence of field strains of Marek’s disease virus (MDV), which can overcome the immunity conferred by the widely used CVI988 vaccine, underscores the need for more effective alternatives.
Ruihan Shi +6 more
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Viruses, 2017 Marek’s disease (MD) virus (MDV) has been evolving continuously, leading to increasing vaccination failure. Here, the MDV field strain BS/15 was isolated from a severely diseased Chinese chicken flock previously vaccinated with CVI988.
Guo-rong Sun +12 more
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Virology Journal, 2009 Background Marek's disease virus (MDV) has a bi-directional promoter between pp38 gene and 1.8-kb mRNA transcripts. By sequencing for the promoters from 8 different strains (CVI988, 814, GA, JM, Md5, G2, RB1B and 648A), it is found, comparing with the ...
Ding Jiabo, Chen Ruiai, Wang Bin
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Interactions between Marek’s disease virus Rispens/CVI988 vaccine strain and adenovirus field strain in chicken embryo fibroblast (CEF) cultures [PDF]
Polish Journal of Veterinary Sciences, 2014 AbstractThe aim of the study was to determine the influence of adenovirus infection on the replication of Marek’s disease virus vaccine strain Rispens/CVI988 during in vitro co-infection studies. Adenovirus field strain JN-5/10j was isolated from sick chickens. The study was conducted in chicken embryo fibroblast cultures (CEF). Monolayers of CEFs were
J S, Niczyporuk +3 more
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Pathogenicity and Pathotype Analysis of Henan Isolates of Marek’s Disease Virus Reveal Long-Term Circulation of Highly Virulent MDV Variant in China [PDF]
Viruses, 2022 In recent years, outbreaks of Marek’s disease (MD) have been frequently reported in vaccinated chicken flocks in China. Herein, we have demonstrated that four Marek’s disease virus (MDV) isolates, HN502, HN302, HN304, and HN101, are all pathogenic and ...
Man Teng +9 more
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International Journal of Poultry Science, 2013 This study was designed to investigate the influence of Gallid herpesvirus 2 Marek's Disease challenge virus and different inoculated routes of attenuated vaccine virus CVI988/Rispens on immune adhesion of erythrocytes in chickens. One day old chicks were randomly divided into a control group (C), an experimental group challenged with Jing-1 challenge ...
W.X. Tian +9 more
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Development of an ELISPOT assay for numerating IFN-γ-secreting T cells in chicken using novel monoclonal antibodies [PDF]
Poultry ScienceCellular immune responses play critical roles in the control of pathogenic infection. The measurement of antigen-specific IFN-γ-secreting T cells via an enzyme-linked immunospot assay (ELISPOT) is a valuable method for the evaluation of cellular immune ...
Zhou Zhou +8 more
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Protection provided by Rispens CVI988 vaccine against Marek's disease virus isolates of different pathotypes and early prediction of vaccine take and MD outcome [PDF]
Avian Pathology, 2016 We tested the level of protection provided by the Rispens CVI988 (Rispens) vaccine against challenge with a virulent Marek's disease virus (MDV) pathotype (vMDV) and a very virulent pathotype (vvMDV) and the accuracy of a range of predictive measures of Marek's disease (MD) incidence and vaccine take.
Sithara, Ralapanawe +3 more
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A Review on the Marek’s Disease Outbreak and Its Virulence-Related meq Genovariation in Asia between 2011 and 2021 [PDF]
Animals, 2022 Marek’s disease is an infectious disease in poultry that usually appears in neural and visceral tumors. This disease is caused by Gallid alphaherpesvirus 2 infection in lymphocytes, and its meq gene is commonly used in virulent studies for coding the key
Baolin Song +9 more
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Surveillance and Molecular Characterization of Marek’s Disease Virus (MDV) Strains Circulating in Tanzania [PDF]
VirusesMarek’s disease (MD) is a highly contagious and oncogenic viral disease of poultry, causing significant economic losses due to mortality and reduced performance. The rapid evolution of Marek’s disease virus (MDV) has been reported in poultry farms, often
Augustino Alfred Chengula +2 more
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