Microbiology Spectrum, 2022 Marek’s disease virus (MDV) induces immunosuppression and neoplastic disease in chickens. The virus is controllable via an attenuated meq deletion mutant virus, which has the disadvantage of retaining the ability to induce lymphoid organ atrophy.
Aijun Sun +10 more
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Viruses, 2020 Marek’s disease virus (MDV), an alpha herpes virus, causes a lymphoproliferative state in chickens known as Marek’s disease (MD), resulting in severe monetary losses to the poultry industry.
Huan Jin +8 more
doaj +1 more source
Microorganisms, 2021 Marek’s disease (MD) is a ubiquitous disease of domesticated chickens and its etiologic agent is the Gallid alphaherpesvirus 2 (GaHV-2), also known as Marek’s disease virus (MDV). MD is currently controlled by vaccination using live attenuated strains of
Steven J. Conrad +4 more
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Molecular characterization of the meq gene of Marek\u2019s disease viruses detected in unvaccinated backyard chickens reveals the circulation of low- and high-virulence strains [PDF]
, 2019 Marek's disease (MD) is an important lymphoproliferative disease of chickens, caused by Gal lid alphaherpesvirus 2 (GaHV-2). Outbreaks are commonly reported in commercial flocks, but also in backyard chickens.
Catelli, E. +6 more
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Evolution of Marek’s disease virus pathogenesis and vaccine resistance [PDF]
, 2021 Vaccines are considered as one of the most significant achievements of modern medicine. The first vaccine that protected animals against cancer is a vaccine designed for Marek’s disease virus.
Conradie, Andelé Marie
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Induction of lymphomas by inoculation of Marek's disease virus-derived lymphoblastoid cell lines: prevention by CVI988 vaccination [PDF]
Avian Pathology, 2012 Lymphoblastoid cell lines 265(L) and 990(O) are monoclonal lymphomas, derived respectively from liver and ovarian tumours, generated in inbred P-line (MHC B(19)/B(19)) chickens infected with RB-1B strain of Marek's disease virus (MDV) and pRB-1B5 BAC clone respectively. These were inoculated into inbred, MDV-susceptible, P-line chickens by intra-venous
Mwangi, W +4 more
openaire +3 more sources
Depression of Vaccinal Immunity to Marek’s Disease by Infection with Chicken Infectious Anemia Virus
Frontiers in Microbiology, 2017 Marek’s disease (MD) has been occurring with increasing frequency in chickens in recent years. To our knowledge, however, there has been no report of the very virulent plus (vv+) MD virus (MDV) field isolate in China.
Yankun Zhang +16 more
doaj +1 more source
Natural outbreak of Marek’s disease in indigenous chicken and Japanese quail (Coturnix coturnix japonica) in Jos, Plateau State, Nigeria [PDF]
Open Veterinary Journal, 2019 Carcasses of an indigenous adult chicken and Japanese quail from different flocks were presented to a veterinary clinic for postmortem (PM) examination in 2014 in Jos, Plateau State, Nigeria.
Adeyinka Jeremy Adedeji +3 more
doaj +1 more source
IFNα and IFNγ Impede Marek’s Disease Progression [PDF]
, 2019 Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D. +6 more
core +1 more source
Marek’s Disease Virus Infection of Natural Killer Cells
Microorganisms, 2019 Natural killer (NK) cells are key players in the innate immune response. They kill virus-infected cells and are crucial for the induction of adaptive immune responses. Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that causes deadly
Luca D. Bertzbach +4 more
doaj +1 more source