Results 31 to 40 of about 397 (126)

The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines

Viruses, 2020
Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative disease caused by Marek’s disease virus (MDV). In recent years, the emergence of very virulent (vv) and/or very virulent plus (vv +) strains of MDV in the field has been ...
Meng-ya Shi, Min Li, Wei-wei Wang, Qiao-mu Deng, Qiu-hong Li, Yan-li Gao, Pei-kun Wang, Teng Huang, Ping Wei   +8 more
doaj   +1 more source

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America [PDF]

, 2017
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus
Groenke, Nicole, He, Shulin, Jenckel, Maria, Kunec, Dusan, McMahon, Dino P., Osterrieder, Nikolaus, Spatz, Stephen J., Szpara, Moriah L., Trimpert, Jakob   +8 more
core   +1 more source

Pathogenicity of a Very Virulent Strain of Marek′s Disease Herpesvirus Cloned as Infectious Bacterial Artificial Chromosomes

BioMed Research International, Volume 2011, Issue 1, 2011., 2011
Bacterial artificial chromosome (BAC) vectors containing the full‐length genomes of several herpesviruses have been used widely as tools to enable functional studies of viral genes. Marek′s disease viruses (MDVs) are highly oncogenic alphaherpesviruses that induce rapid‐onset T‐cell lymphomas in chickens. Oncogenic strains of MDV reconstituted from BAC
Lorraine P. Smith, Lawrence J. Petherbridge, Susan J. Baigent, Jennifer Simpson, Venugopal Nair, Gregory Tannock   +5 more
wiley   +1 more source

Attenuation of a recombinant Marek's disease virus lacking the meq oncogene and evaluation on its immune efficacy against Marek's disease virus

Poultry Science, 2020
SC9-2 is a recombinant Marek's disease virus (MDV) strain lacking the meq oncogene. Previous study demonstrated that SC9-2 virus provides good protection against challenge with a very virulent MDV rMd5, but it induces immunosuppressive effects in ...
Peng Sun, Ning Cui, Linqing Liu, Shuai Su, Ziqiang Cheng, Ruiai Chen, Yanpeng Li, Zhizhong Cui   +7 more
doaj   +1 more source

Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines. [PDF]

PLoS ONE, 2012
Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks ...
Kai Wei, Zhenhong Sun, Shufen Zhu, Wenlong Guo, Pengcheng Sheng, Zunmin Wang, Changliang Zhao, Qingyou Zhao, Ruiliang Zhu   +8 more
doaj   +1 more source

Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance [PDF]

, 2020
Modified-live herpesvirus vaccines are widely used in humans and animals, but field strains can emerge that have a higher virulence and break vaccinal protection.
Bertzbach, Luca D., Conradie, Andelé M., Kaufer, Benedikt B., Murata, Shiro, Parcells, Mark S., Patria, Joseph N., Trimpert, Jakob   +6 more
core   +1 more source

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence

Viruses, 2022
Marek’s disease virus (MDV) causes malignant lymphoma in chickens (Marek’s disease, MD). Although MD is currently controlled by vaccination, MDV strains have continuously increased in virulence over the recent decades.
Jumpei Sato, Shiro Murata, Zhiyuan Yang, Benedikt B. Kaufer, Sotaro Fujisawa, Hikari Seo, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Nikolaus Osterrieder, Mark S. Parcells, Kazuhiko Ohashi   +11 more
doaj   +1 more source

The Role of Dendritic Cells in the Host Response to Marek’s Disease Virus (MDV) as Shown by Transcriptomic Analysis of Susceptible and Resistant Birds [PDF]

, 2022
Despite the successful control of highly contagious tumorigenic Marek’s disease (MD) by vaccination, a continuous increase in MD virus (MDV) virulence over recent decades has put emphasis on the development of more MD-resistant chickens.
Chakraborty , Pankaj, Dutia, Bernadette, Kaiser, Pete, Kuo, Richard, Morris, Katrina, Smith, Jacqueline, Wu, Zhou   +6 more
core   +2 more sources

Identification of Mardivirus Serotypes Circulating in Poultry Farms in Sukabumi and Cianjur District, West Java, 2011 using Multiplex Polymerase Chain Reaction (mPCR) Approach [PDF]

, 2013
Three serotypes of Mardivirus had been circulating in the farm environments, these being Marek’s disease virus serotype 1 (MDV-1), Gallid hepesvirus 3 (GaHV3) and herpesvirus of turkey (HVT).
Hartawan, Risza, NLPI, DharmayantI
core   +3 more sources

Protection provided by Rispens CVI988 vaccine against Marek's disease virus isolates of different pathotypes and early prediction of vaccine take and MD outcome [PDF]

Avian Pathology, 2016
We tested the level of protection provided by the Rispens CVI988 (Rispens) vaccine against challenge with a virulent Marek's disease virus (MDV) pathotype (vMDV) and a very virulent pathotype (vvMDV) and the accuracy of a range of predictive measures of Marek's disease (MD) incidence and vaccine take.
Sithara, Ralapanawe, Stephen W, Walkden-Brown, Katrin G, Renz, A F M Fakhrul, Islam   +3 more
openaire   +2 more sources