Results 11 to 20 of about 518 (147)

Real-time PCR for differential quantification of CVI988 vaccine virus and virulent strains of Marek’s disease virus [PDF]

Journal of Virological Methods, 2016
CVI988/Rispens vaccine, the 'gold standard' vaccine against Marek's disease in poultry, is not easily distinguishable from virulent strains of Marek's disease herpesvirus (MDV). Accurate differential measurement of CVI988 and virulent MDV is commercially important to confirm successful vaccination, to diagnose Marek's disease, and to investigate causes
Venugopal Nair, Susan J Baigent
exaly   +4 more sources

Depression of Vaccinal Immunity to Marek’s Disease by Infection with Chicken Infectious Anemia Virus [PDF]

Frontiers in Microbiology, 2017
Marek’s disease (MD) has been occurring with increasing frequency in chickens in recent years. To our knowledge, however, there has been no report of the very virulent plus (vv+) MD virus (MDV) field isolate in China.
Yankun Zhang, Yankun Zhang, Yankun Zhang, Ning Cui, Ning Cui, Ning Cui, Ning Cui, Ni Han, Ni Han, Ni Han, Jiayan Wu, Jiayan Wu, Jiayan Wu, Zhizhong Cui, Shuai Su, Shuai Su, Shuai Su   +16 more
doaj   +2 more sources

Induction of lymphomas by inoculation of Marek's disease virus-derived lymphoblastoid cell lines: prevention by CVI988 vaccination [PDF]

Avian Pathology, 2012
Lymphoblastoid cell lines 265(L) and 990(O) are monoclonal lymphomas, derived respectively from liver and ovarian tumours, generated in inbred P-line (MHC B(19)/B(19)) chickens infected with RB-1B strain of Marek's disease virus (MDV) and pRB-1B5 BAC clone respectively. These were inoculated into inbred, MDV-susceptible, P-line chickens by intra-venous
Mwangi, W, Smith, L, Baigent, S, Smith, A, Nair, V   +4 more
openaire   +5 more sources

Transcriptional Profiles Associated with Marek’s Disease Virus in Bursa and Spleen Lymphocytes Reveal Contrasting Immune Responses during Early Cytolytic Infection

Viruses, 2020
Marek’s disease virus (MDV), an alpha herpes virus, causes a lymphoproliferative state in chickens known as Marek’s disease (MD), resulting in severe monetary losses to the poultry industry.
Huan Jin, Zimeng Kong, Arslan Mehboob, Bo Jiang, Jian Xu, Yunhong Cai, Wenxiao Liu, Jiabing Hong, Yongqing Li   +8 more
doaj   +2 more sources

Pathology and Molecular Diagnosis of Marek's Disease Virus in Chickens in Nigeria. [PDF]

Scientifica (Cairo)
Marek’s disease caused by Marek’s disease virus (MDV) serotype 1 is an economically important neoplastic disease of poultry. Diagnosis of this disease is usually based on clinical signs, postmortem lesions, and diagnostic tests like cytology, histopathology, and molecular‐based methods.
Fagbohun OA, Oluladun AC, Jarikre TA, Alaka OO, Oyagbemi AA, Adesina RD, Esan OO, Akinniyi OO, Adetona MO, Omobowale TO, Mamoh UJ, Jaja IF.   +11 more
europepmc   +2 more sources

High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions. [PDF]

PLoS Pathogens
Comparative genomic studies of Marek's disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tandem repeats.
Alejandro Ortigas-Vasquez, Christopher D Bowen, Daniel W Renner, Susan J Baigent, Yaoyao Zhang, Yongxiu Yao, Venugopal Nair, David A Kennedy, Moriah L Szpara   +8 more
doaj   +3 more sources

Regulation of Wnt/β-catenin signaling by Marek’s disease virus in vitro and in vivo [PDF]

Frontiers in Microbiology
Marek’s disease virus (MDV) infection causes immunosuppression in the host, ultimately inducing tumor formation and causing significant economic losses to the poultry industry.
Haiyin Xu, Haiyin Xu, Xihao Xu, Xihao Xu, Huifeng He, Huifeng He, Hongxia Shao, Hongxia Shao, Hongxia Shao, Yongxiu Yao, Aijian Qin, Aijian Qin, Aijian Qin, Kun Qian, Kun Qian, Kun Qian   +15 more
doaj   +2 more sources

Genomic analysis of a Chinese MDV strain derived from vaccine strain CVI988 through recombination

Infection, Genetics and Evolution, 2020
Disease caused by Marek's disease virus (MDV), a highly oncogenic alpha-herpesvirus, is controlled mainly by vaccination. Since 1990s, CVI988 has been widely used as vaccine strain. However, as an attenuated live vaccine, CVI988 has the potential of virulence enhancement and the risk of recombination that should be considered.
Yongchang Cao, Juo Luo
exaly   +3 more sources

Differences in Pathogenicity and Vaccine Resistance Discovered between Two Epidemic Strains of Marek’s Disease Virus in China [PDF]

Viruses, 2023
Despite highly effective vaccines, Marek’s disease (MD) causes great economic loss to the poultry industry annually, largely due to the continuous emergence of new MD virus (MDV) strains.
Zheng-Hao Yu, Yan-Ping Zhang, Xing-Ge Lan, Ya-Nan Wang, Rong-Rong Guo, Kai Li, Li Gao, Xiao-Le Qi, Hong-Yu Cui, Xiao-Mei Wang, Yu-Long Gao, Chang-Jun Liu   +11 more
doaj   +2 more sources

Research note: A novel double-gene deleted vaccine against hypervirulent MDV variant generated by CRISPR/Cas9-based gene editing [PDF]

Poultry Science
Marek’s disease (MD), an important avian immunosuppressive and neoplastic diseases, has resulted in huge economic losses for the poultry industry worldwide.
Lu Han, Shu-Ge Wang, Man Teng, Lu-Ping Zheng, Si-Yu Ge, Qian Mao, Fang Han, Liu Yang, Shu-Jun Chai, Qin Luo, Yongxiu Yao, Zu-Hua Yu, Jun Luo   +12 more
doaj   +2 more sources