Results 11 to 20 of about 354 (118)

Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines [PDF]

Viruses, 2023
As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-Ling Liu, Man Teng, Lu-Ping Zheng, Feng-Xia Zhu, Shu-Xue Ma, Lin-Yan Li, Zhi-Hui Zhang, Shu-Jun Chai, Yongxiu Yao, Jun Luo   +9 more
doaj   +2 more sources

The emergence of a highly pathogenic marek’s disease virus featuring newly identified mutations in Meq oncogene in Southern China [PDF]

Virology Journal
Background Marek’s disease virus (MDV) is a significant threat to global poultry health, causing high mortality, tumor formation, and severe immunosuppression, leading to substantial economic losses.
Qiong Luo, Huimin Li, Zengxu Ge, Zhanhong Chen, Ruiai Chen   +4 more
doaj   +2 more sources

Fully Attenuated meq and pp38 Double Gene Deletion Mutant Virus Confers Superior Immunological Protection against Highly Virulent Marek’s Disease Virus Infection [PDF]

Microbiology Spectrum, 2022
Marek’s disease virus (MDV) induces immunosuppression and neoplastic disease in chickens. The virus is controllable via an attenuated meq deletion mutant virus, which has the disadvantage of retaining the ability to induce lymphoid organ atrophy.
Aijun Sun, Xuyang Zhao, Xiaojing Zhu, Zhengjie Kong, Yifei Liao, Man Teng, Yongxiu Yao, Jun Luo, Venugopal Nair, Guoqing Zhuang, Gaiping Zhang   +10 more
doaj   +2 more sources

Pathology and Molecular Diagnosis of Marek’s Disease Virus in Chickens in Nigeria [PDF]

Scientifica, Volume 2025, Issue 1, 2025.
Marek’s disease caused by Marek’s disease virus (MDV) serotype 1 is an economically important neoplastic disease of poultry. Diagnosis of this disease is usually based on clinical signs, postmortem lesions, and diagnostic tests like cytology, histopathology, and molecular‐based methods.
Olusegun Adesina Fagbohun, Aiki-Raji Comfort Oluladun, Theophilus Aghogho Jarikre, Olugbenga Olayinka Alaka, Ademola Adetokunbo Oyagbemi, Rofiat Damilola Adesina, Oluwaseun Olanrewaju Esan, Olumide Odunayo Akinniyi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Ufuoma Joan Mamoh, Ishmael Festus Jaja, Amir Sasan Mozaffari Nejad   +12 more
wiley   +2 more sources

High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions. [PDF]

PLoS Pathogens
Comparative genomic studies of Marek's disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tandem repeats.
Alejandro Ortigas-Vasquez, Christopher D Bowen, Daniel W Renner, Susan J Baigent, Yaoyao Zhang, Yongxiu Yao, Venugopal Nair, David A Kennedy, Moriah L Szpara   +8 more
doaj   +3 more sources

Regulation of Wnt/β-catenin signaling by Marek’s disease virus in vitro and in vivo [PDF]

Frontiers in Microbiology
Marek’s disease virus (MDV) infection causes immunosuppression in the host, ultimately inducing tumor formation and causing significant economic losses to the poultry industry.
Haiyin Xu, Haiyin Xu, Xihao Xu, Xihao Xu, Huifeng He, Huifeng He, Hongxia Shao, Hongxia Shao, Hongxia Shao, Yongxiu Yao, Aijian Qin, Aijian Qin, Aijian Qin, Kun Qian, Kun Qian, Kun Qian   +15 more
doaj   +2 more sources

Deletion of the Viral Thymidine Kinase in a Meq-Deleted Recombinant Marek’s Disease Virus Reduces Lymphoid Atrophy but Is Less Protective [PDF]

Microorganisms, 2021
Marek’s disease (MD) is a ubiquitous disease of domesticated chickens and its etiologic agent is the Gallid alphaherpesvirus 2 (GaHV-2), also known as Marek’s disease virus (MDV). MD is currently controlled by vaccination using live attenuated strains of
Steven J. Conrad, Eniope B. Oluwayinka, Mohammad Heidari, Jody K. Mays, John R. Dunn   +4 more
doaj   +2 more sources

Differences in Pathogenicity and Vaccine Resistance Discovered between Two Epidemic Strains of Marek’s Disease Virus in China [PDF]

Viruses, 2023
Despite highly effective vaccines, Marek’s disease (MD) causes great economic loss to the poultry industry annually, largely due to the continuous emergence of new MD virus (MDV) strains.
Zheng-Hao Yu, Yan-Ping Zhang, Xing-Ge Lan, Ya-Nan Wang, Rong-Rong Guo, Kai Li, Li Gao, Xiao-Le Qi, Hong-Yu Cui, Xiao-Mei Wang, Yu-Long Gao, Chang-Jun Liu   +11 more
doaj   +2 more sources

Research note: A novel double-gene deleted vaccine against hypervirulent MDV variant generated by CRISPR/Cas9-based gene editing [PDF]

Poultry Science
Marek’s disease (MD), an important avian immunosuppressive and neoplastic diseases, has resulted in huge economic losses for the poultry industry worldwide.
Lu Han, Shu-Ge Wang, Man Teng, Lu-Ping Zheng, Si-Yu Ge, Qian Mao, Fang Han, Liu Yang, Shu-Jun Chai, Qin Luo, Yongxiu Yao, Zu-Hua Yu, Jun Luo   +12 more
doaj   +2 more sources

Pathogenicity and Pathotype Analysis of Henan Isolates of Marek’s Disease Virus Reveal Long-Term Circulation of Highly Virulent MDV Variant in China [PDF]

Viruses, 2022
In recent years, outbreaks of Marek’s disease (MD) have been frequently reported in vaccinated chicken flocks in China. Herein, we have demonstrated that four Marek’s disease virus (MDV) isolates, HN502, HN302, HN304, and HN101, are all pathogenic and ...
Man Teng, Lu-Ping Zheng, Hui-Zhen Li, Sheng-Ming Ma, Zhi-Jian Zhu, Shu-Jun Chai, Yongxiu Yao, Venugopal Nair, Gai-Ping Zhang, Jun Luo   +9 more
doaj   +2 more sources