Results 11 to 20 of about 397 (126)

The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes [PDF]

Viruses, 2019
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and poses a serious threat to poultry health. In infected animals, MDV efficiently replicates in B cells in various lymphoid organs.
Bertzbach, Luca D., Härtle, Sonja, Höper, Dirk, Karger, Axel, Kaufer, Benedikt B., Kheimar, Ahmed M., Pauker, Viktoria I., Pfaff, Florian   +7 more
core   +4 more sources

A common live-attenuated avian herpesvirus vaccine expresses a very potent oncogene [PDF]

mSphere, 2019
Vaccines play a crucial role in the protection of animals and humans from deadly pathogens. The first vaccine that also protected against cancer was developed against the highly oncogenic herpesvirus Marek’s disease virus (MDV).
Bertzbach, Luca D., Bhandari, Nirajan, Conradie, Andelé M.   +2 more
core   +3 more sources

Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus

Viruses
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence. The attenuated vaccine strain CVI988 harbors unique amino acid polymorphisms in Meq, particularly at positions 71 ...
Jumpei Sato, Yoshinosuke Motai, Shunsuke Yamagami, Aoi Kurokawa, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata   +11 more
openaire   +4 more sources

Comparative analysis of oncogenic genes revealed unique evolutionary features of field Marek's disease virus prevalent in recent years in China [PDF]

Virology Journal, 2011
Background Marek's disease (MD) is an economically important viral disease of chickens caused by Marek's disease virus (MDV), an oncogenic herpesvirus.
Mingxing Tian, Yang Zhao, Yan Lin, Nianli Zou, Cheng Liu, Ping Liu, Sanjie Cao, Xintian Wen, Yong Huang   +8 more
core   +4 more sources

An Anti-Tumor Vaccine Against Marek's Disease Virus Induces Differential Activation and Memory Response of γδ T Cells and CD8 T Cells in Chickens

Frontiers in Immunology, 2021
Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens.
Xiaoli Hao, Xiaoli Hao, Xiaoli Hao, Shuai Li, Jiaqi Li, Yi Yang, Yi Yang, Yi Yang, Aijian Qin, Aijian Qin, Aijian Qin, Aijian Qin, Shaobin Shang, Shaobin Shang, Shaobin Shang, Shaobin Shang   +15 more
doaj   +1 more source

A quadruplex real-time PCR assay combined with a conventional PCR for the differential detection of Marek’s disease virus vaccines and field strains

Frontiers in Veterinary Science, 2023
To evaluate the effect of the vaccine and differentiate vaccine from virulent MDV, a new quadruplex real-time PCR assay based on TaqMan probes was developed to differentiate and accurately quantify HVT, CVI988 and virulent MDV-1.
Shaopeng Wu, Shaopeng Wu, Shaopeng Wu, Tian Ding, Tian Ding, Tian Ding, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +17 more
doaj   +1 more source

Genetic evolution of Marek's disease virus in vaccinated poultry farms [PDF]

Veterinary World, 2021
Background and Aim: The Marek's disease virus (MDV) is a neoplastic disease causing serious economic losses in poultry production. This study aimed to investigate MDV occurrence in poultry flocks in the Lower Egypt during the 2020 breakout and ...
Nahed Yehia, Hemat S. El-Sayed, Sabry E. Omar, Ahmed Erfan, Fatma Amer   +4 more
doaj   +1 more source

Differential Replication and Cytokine Response between Vaccine and Very Virulent Marek’s Disease Viruses in Spleens and Bursas during Latency and Reactivation

Viruses, 2022
Marek’s disease virus (MDV) infection results in Marek’s disease (MD) in chickens, a lymphoproliferative and oncogenic deadly disease, leading to severe economic losses. The spleen and bursa are the most important lymphoid and major target organs for MDV
Bo Jiang, Jing Wang, Mengyao Cao, Huan Jin, Wenxiao Liu, Jing Cheng, Linyi Zhou, Jian Xu, Yongqing Li   +8 more
doaj   +1 more source

Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines

Viruses, 2023
As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-Ling Liu, Man Teng, Lu-Ping Zheng, Feng-Xia Zhu, Shu-Xue Ma, Lin-Yan Li, Zhi-Hui Zhang, Shu-Jun Chai, Yongxiu Yao, Jun Luo   +9 more
doaj   +1 more source

Marek’s disease vaccines-induced differential expression of known and novel microRNAs in primary lymphoid organ bursae of White Leghorn

Veterinary Research, 2020
Marek’s disease (MD) is a contagious disease of domestic chickens caused by MD viruses. MD has been controlled primarily by vaccinations, yet sporadic outbreaks of MD take place worldwide.
Lei Zhang, Chen Zhu, Mohammad Heidari, Kunzhe Dong, Shuang Chang, Qingmei Xie, Huanmin Zhang   +6 more
doaj   +1 more source