Results 111 to 120 of about 21,433 (201)

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Alteration of Cx43:Cx40 expression ratio in A7r5 cells

, 2001
Connexins (Cx) 40 and 43 are coexpressed by several cell types at ratios that vary as a function of development, aging, and disease. Because these connexins form heteromeric channels, changes in expression ratio might be expected to significantly alter ...
Yan Wu, G. Trevor Cottrell, David T. Kurjiaka, Anna M. Fletcher, Timothy D. Steele, Janis M. Burt   +5 more
core   +1 more source

Nut Consumption and Sperm Quality in Healthy Men: Results From the Led‐Fertyl Study

Andrology, Volume 14, Issue 7, Page 2262-2273, October 2026.
ABSTRACT Background Nuts are rich in antioxidants and other bioactive compounds, and recent evidence suggests that their regular consumption may be associated with sperm quality. However, the current scientific evidence remains limited and inconsistent.
Estefanía Dávila‐Córdova, Nancy Babio, Cristina Valle‐Hita, María Fernández de la Puente, Alfonso Beltran‐Arasa, Miguel Cebrián‐Puig, Violeta Fambuena‐Perez, Iván García‐Serrano, Michelle M. Murphy, Jordi Salas‐Salvadó, Albert Salas‐Huetos   +10 more
wiley   +1 more source

siRNA-mediated downregulation of Cx43 in hASCs.

, 2013
The time-dependent, siRNA-mediated downregulation of Cx43 in hASCs was investigated by qRT-PCR (A) and Western blot analysis (B). Immunocytochemical analysis confirmed the Cx43 downregulation in hASCs after 3 days of siRNA treatment (C).
Dong Ryul Lee (141574), Sung Han Shim (141576), Hee-Chun Kim (437997), Won Kim (437999), Soo-Hong Lee (438000), Daekee Kwon (437995), Jin-Su Kim (437994), Hansoo Park (437998), Myung-Kwan Han (171079), Seung-Taeh Hwang (437996)   +9 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, Volume 36, Issue 75, 17 September 2026.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Distribution of Cx43 in COC sections.

, 2013
A) COC matured in hCG medium for 8.5 h. B) COC matured in eCG/MG132 medium for 8.5 h. A/B) sections stained with anti-Cx43 to reveal connexin 43 proteins (green); A’/B’) sections stained with DAPI to reveal the nucleus; A”/B”) bright-field picture of COC
Nicolas Santiquet (430436), Claude Robert (255405), François J. Richard (430437)   +2 more
core   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Biomolecules
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation.
Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz   +4 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Shikonin promotes osteogenic differentiation of periodontal ligament stem cells by modulating the p38 MAPK/ETS transcription factor 1/cementum protein 1 axis in vitro

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Our study revealed that Shikonin enhanced osteogenic differentiation by promoting the ELK1/CEMP1 axis via the activation of p38 MAPK signaling in PDLSCs. This indicated that Shikonin may serve as a candidate drug, while the ELK1/CEMP1 axis may be identified as a valuable pathway for promoting the osteogenic differentiation of PDLSCs.
Zeyu Wu, Chao Shan, Jie Song, Qian Yu, Bing‐jie Lian, Jin Zhao   +5 more
wiley   +1 more source