Results 91 to 100 of about 21,433 (201)
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat +6 more
wiley +1 more source
Functional characteristics of heterogeneous Cx40/Cx43 gap junction channel formation
, 2001 Cells of the cardiovascular system express multiple connexins (Cx) with Cx40 and Cx43 being commonly coexpressed in many tissues. The expression levels of connexins are dynamic and can vary in response to a growth stimulus.
Cottrell, Graham Trevor
core +4 more sources
Mechanism of Regulatory Effect of MicroRNA-206 on Connexin 43 in Distant Metastasis of Breast Cancer
Chinese Medical Journal, 2016 Background: MicroRNA-206 (miR-206) and connexin 43 (Cx43) are related with the distant metastasis of breast cancer. It remains unclear whether the regulatory effect of miR-206 on Cx43 is involved in metastasis of breast cancer.
Zi-Jing Lin +5 more
doaj +1 more source
Spatiotemporal movement of Cx43 towards the intercalated disc.
, 2014 Double labeling of Cx43 (green) and α-actinin (red) at different stages of cardiac development. Cx43 (green) Cx43 moves from the lateral side of the myocytes towards the IDs.
Toon A. B. van Veen (350437) +5 more
core +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
, 2013 (A) Cx43-LLC-PK1 cells and LLC-PK1 cells were cultured in 1∶4 proportions. The number and localization of Cx43-EGFP positive cells under fluorescent microscope in the mixed culture is shown (upper panel, images under light and fluorescent microscope ...
Kun Gao (161056) +7 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier +3 more
wiley +1 more source
Modulation of connexin 43 in viral infections
Tumour Virus ResearchConnexins are essential for intercellular communication through gap junctions and the maintenance of cellular and tissue homeostasis. Connexin 43 (Cx43) is the most ubiquitously expressed connexin. As well as regulating homeostasis, Cx43 hemichannels and
Harry Scott +2 more
doaj +1 more source
OGD induced uncoupling of CT truncated Cx43 (Cx43-ΔΔ257).
, 2013 A. Gj of CT truncated Cx43 reduced to a lesser extent compared to wild type Cx43, in response to OGD. B. quantitative representation of data generated from 5–7 independent experiments.
Amal Kanti Bera (394237) +1 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli +12 more
wiley +1 more source