Results 71 to 80 of about 34,737 (208)

Identification of Potential Therapeutic Targets Among CXC Chemokines in Breast Tumor Microenvironment Using Integrative Bioinformatics Analysis

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: Breast cancer is a common cause of cancer mortality throughout the world. The cross-talk between cancer cells and interstitial cells exerts significant effects on neoplasia and tumor development and is modulated in part by chemokines ...
Erbao Chen   +9 more
doaj   +1 more source

CXC Chemokines in Cancer Angiogenesis and Metastases [PDF]

open access: yes, 2010
The tumor microenvironment is extremely complex that depends on tumor cell interaction with the responding host cells. Angiogenesis, or new blood vessel growth from preexisting vasculature, is a preeminent feature of successful tumor growth of all solid tumors.
Ellen C, Keeley   +2 more
openaire   +2 more sources

Angiotensin II Induces Neutrophil Accumulation In Vivo Through Generation and Release of CXC Chemokines [PDF]

open access: yes, 2004
Background— Angiotensin II (Ang II) is implicated in the development of cardiac ischemic disorders in which prominent neutrophil accumulation occurs. Ang II can be generated intravascularly by the renin-angiotensin system or extravascularly by mast cell ...
Abu Nabah, Yafa Naim   +9 more
core   +2 more sources

The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

open access: yesFrontiers in Immunology, 2018
The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development.
Veronika Szentes   +3 more
doaj   +1 more source

Proinflammatory chemokines in the development of systemic organ-specific sensitization in infectious corneal ulcers

open access: yesРоссийский офтальмологический журнал, 2020
Purpose. The aim is to estimate the content of proinflammatory chemokines (CXCL1/GRO-α CXCL8/IL-8, CXCL10/IP-10, CXCL12/ SDF-1α, CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL11/Eotaxin) in blood serum in corneal ulcers and their relationship to ...
N. V. Balatskaya   +3 more
doaj   +1 more source

Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND:Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR(+)) chemokine family are powerful promoters of the angiogenic response.
Anne-Marie Baird   +2 more
doaj   +1 more source

Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. [PDF]

open access: yes, 2018
Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE.
Doty, Daniel J   +7 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

open access: yesIbrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Chemokine expression and viral infection of the central nervous system: regulation of host defense and neuropathology. [PDF]

open access: yes, 2001
An effective host response against viral infection of the central nervous system (CNS) is the principal factor dictating the outcome of infection. It is the responsibility of the immune response to contain and control viral replication. Paradoxically, it
Lane, TE, Liu, MT
core  

Experimental Validation of an Immune Cell Infiltration Signature in Psoriasis: Translating Computational Modeling to In Vivo Efficacy

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We calculated the infiltration profiles of 28 immune cells within psoriatic immune microenvironment through single‐sample gene set enrichment analysis (ssGSEA) algorithm based on the eleven psoriasis related microarray datasets. Five immune‐related genes CXCL8, CXCL9, CCL18, RGS1, and SAMSN1 are associated with psoriasis, and establish a predictive ...
Tingjin Zheng   +7 more
wiley   +1 more source

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