Results 91 to 100 of about 68,560 (212)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Evolutionarily conserved mechanisms regulating stress-induced neutrophil redistribution in fish

Frontiers in Immunology
IntroductionStress may pose a serious challenge to immune homeostasis. Stress however also may prepare the immune system for challenges such as wounding or infection, which are likely to happen during a fight or flight stress response.MethodsIn common ...
Katarzyna Klak, Katarzyna Klak, Magdalena Maciuszek, Lukasz Pijanowski, Magdalena Marcinkowska, Magdalena Marcinkowska, Joanna Homa, B. M. Lidy Verburg-van Kemenade, Krzysztof Rakus, Magdalena Chadzinska   +9 more
doaj   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke

, 2011
The definition of ischaemic stroke has been recently updated as an acute episode of neurological dysfunction caused by focal brain, spinal cord, or retinal ischaemia in the presence of a cerebral infarction. This "tissular" definition has highlighted the
DALLEGRI, FRANCO, QUERCIOLI, ALESSANDRA MARIA, BRAUNERSREUTHER V, VIVIANI, GIORGIO LUCIANO, MACH F, VENESELLI, EDVIGE MARIA, MIRABELLI BADENIER M, MONTECUCCO, FABRIZIO, Edvige Veneselli, Fabrizio Montecucco, Marisol Mirabelli-Badenier, François Mach, Vincent Braunersreuther, Giorgio Luciano Viviani, Franco Dallegri, Alessandra Quercioli   +15 more
core   +1 more source

Neuropsychiatric symptom improvement and biomarker changes with electroacupuncture in adolescent and young adult cancer survivors: A randomized pilot trial

Pediatric, Adolescent &Young Adult Cancer, Volume 1, Issue 1, November 2026.
Abstract Introduction Electroacupuncture (EA) shows promise for managing neuropsychiatric symptoms, yet its role in adolescents and young adults (AYAs) living with cancer remains unclear. This is a randomized, controlled, patient‐blinded and assessor‐blinded pilot trial comparing two EA regimens to evaluate the improvement of neuropsychiatric symptoms ...
Alexandre Chan, Matthew Heshmatipour, Ding Quan Ng, Julia Trudeau, Munjal M. Acharya, Anshu Agrawal, Shaista Malik, Lifang Xie, Yae Chang, Keri Zabokrtsky, Christine Yun, Carol Lin, Sonia Morales, Jamie Frediani, Lilibeth Torno   +14 more
wiley   +1 more source

Corneal and Conjunctival Fibroblasts Are Major Sources of Eosinophil-Recruiting Chemokines

Allergology International, 2009
Background: Differential expression of chemokine genes were investigated in various types of ocular surface cells. Methods: Primary cultures of human corneal epithelial cells (n = 3), corneal fibroblasts (n = 2), conjunctival epithelial cells (n = 2) and
Kazumi Fukagawa, Naoko Okada, Hiroshi Fujishima, Toshiharu Nakajima, Yoji Takano, Mari Tanaka, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Hirohisa Saito   +9 more
doaj   +1 more source

Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array [PDF]

, 2010
Chemokines recruit and activate leukocytes, assisting granuloma formation. Herein, we evaluated plasma chemokines in patients with active tuberculosis (ATB) and after completing treatment (TTB) and compared them to BCG-vaccinated healthy controls (HC ...
Abramo, Clarice, Alves, Caio César de Souza, Teixeira, Henrique Couto, Almeida, Caroline de Souza, Ferreira, Ana Paula, Mazzoccoli, Luciano   +5 more
core  

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source

Breast tumor cell soluble factors induce monocytes to produce angiogenic but not angiostatic CXC chemokines

, 2005
Tumor cells are known to interact closely with nontumoral infiltrating cells in order to grow and proliferate. Monocyte-derived cells constitute a major component of the tumoral infiltrate and a high level of these cells has been associated with ...
Eliaou, J. F., Frédéric Toulza, Jean-François Eliaou, Pinet, V., Toulza, F., Valérie Pinet   +5 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source