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CXCL12: Role in neuroinflammation
The International Journal of Biochemistry & Cell Biology, 2012 CXCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors, CXCR4 and CXCR7.
Timotijević, Gordana S +2 more
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Pathological roles of the homeostatic chemokine CXCL12
Cytokine and Growth Factor Reviews, 2018 CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various ...
Paul Proost +2 more
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CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration
Cellular Signalling, 2020Despite improvements in cancer early detection and treatment, metastatic breast cancer remains deadly. Current therapeutic approaches have very limited efficacy in patients with triple negative breast cancer. Among the many mechanisms associated that contribute to cancer progression, signaling through the CXCL12-CXCR4 is an essential step in cancer ...
Irina Nesmelova +2 more
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CXCL12-γ expression is inhibited in neuroinflammation
Brain Research, 2013 CXCL12 plays a protective role in CNS autoimmunity. Expression of CXCL12-γ, which has distinct structural and functional properties than the other isoforms of CXCL12, was determined in spinal cords of rats immunized to develop experimental autoimmune encephalomyelitis (EAE).
Timotijević, Gordana S +5 more
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CXCR7 impact on CXCL12 biology and disease
Trends in Molecular Medicine, 2013It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive ...
Paloma Sánchez-Mateos +1 more
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CXCL12 Signaling in the Tumor Microenvironment
2021Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling molecules. Chemokines and their receptors play a fundamental role in the crosstalk between tumor cells and TME, regulating tumor-related angiogenesis, specific leukocyte ...
Luigi, Portella +2 more
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CXCL12 in control of neuroinflammation
Immunologic Research, 2012Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (
Momčilović, Miljana +2 more
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The role of CXCL12 in tumor microenvironment
Gene, 2018The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment.
Wenfang Meng, Shihang Xue, Ye Chen
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The role of the chemokine CXCL12 in osteoclastogenesis
Trends in Endocrinology & Metabolism, 2007The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the ...
Gronthos, S., Zannettino, A.
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