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The CXCR4/CXCL12 axis in endometrial cancer
Clinical & Experimental Metastasis, 2009Chemokines and their receptors seem to act as important regulators of the metastatic cascade. CXCL12 and its receptor CXCR4 were shown to be involved in human cancer progression. There is increasing evidences suggesting that the expression of CXCR4 in human cancers is correlated with poor patient prognosis and that CXCR4 neutralization can prevent ...
GELMINI, STEFANIA +9 more
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CXCL12 in normal and pathological pregnancies: A review
American Journal of Reproductive Immunology, 2020AbstractThe survival of allogeneic fetuses during pregnancy is a rather paradoxical phenomenon with a complex mechanism. Chemokine ligand12 (CXCL12) and its receptors CXC chemokine receptor (CXCR)4 and 7 are extensively found in placenta tissues and cells, including trophoblast cells, vascular endothelial cells, and decidual stromal and decidual immune
Deng Ao, Da‐Jin Li, Ming‐Qing Li
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CXCL12 and CXCR4 in bone marrow physiology
Expert Review of Hematology, 2010This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis.
Natalia M, Moll, Richard M, Ransohoff
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Science Signaling, 2017
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
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The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
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CXCR7, CXCR4 and CXCL12: An eccentric trio?
Journal of Neuroimmunology, 2008CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
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Functions of CXCL12 and CXCR4 in breast cancer
Cancer Letters, 2006The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 were first identified in the context of trafficking and homeostasis of immune cells, such as T lymphocytes. Subsequently, it has been determined that CXCR4 regulates several key processes in a wide variety of cancers.
Kathryn E, Luker, Gary D, Luker
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CXCR4/CXCL12 as a Therapeutic Target
2014The interaction of acute myeloid leukemia (AML) blasts with the bone marrow microenvironment regulates critical processes important in sustaining the malignant clone including self-renewal, cell growth, and proliferation as well as resistance to chemotherapy.
Geoffrey L. Uy, John F. DiPersio
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ความสำคัญและที่มาปัญหาการวิจัย : 14-40% ผู้ป่วยมะเร็งปอดชนิดไม่เล็กระยะลุกลามจะเกิดมะเร็งกระจายไปที่กระดูกและประมาณครึ่งหนึ่งจะเกิดภาวะแทรกซ้อนตามมา (1) ซึ่งมีผลต่อคุณภาพชีวิตและอัตราการรอดชีวิตที่ 2 ปี เท่ากับ 11.3%(2) ถึงแม้ว่าการทำ Bone scan และ FDG-PET จะมีความไวและความจำเพาะที่สูง แต่ก็ยังพบว่ามีผลลบและผลบวกลวงได้ในชนิดมะเร็งที่มีการกัดกร่อนท ...
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CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis
Ageing Research Reviews, 2023Yang Yang, Wangrui Lei, Ran Tang
exaly
Glioblastomas: Role of CXCL12 Chemokine
2010Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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