Results 231 to 240 of about 94,110 (297)

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Ligand-regulated ACKR3 nanoclustering shapes CXCR4 signaling at the plasma membrane

Santander-Acerete N, García-Cuesta EM, Gardeta SR, Villares R, Artinger M, Gerken OJ, Bueno RA, Leurs R, Vischer HF, Cayuela A, Mateos N, Palacios BS, Rodríguez-Frade JM, Legler DF, Mellado M.   +14 more
europepmc   +1 more source

Regulatory logic underlying neural crest contributions to the head versus the heart. [PDF]

Proc Natl Acad Sci U S A
Gandhi S, Rajan ARD, Urrutia H, Wilson JS, Ling ITC, Williams R, Sauka-Spengler T, Bronner ME.   +7 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Selected Chemokines as Prognostic Biomarkers and Therapeutic Targets in Ovarian Cancer. [PDF]

Curr Issues Mol Biol
Długaszek A, Kabut J, Domagała-Haduch M, Gorzelak-Magiera A, Sadurska J, Morawiec ML, Mielczarek-Palacz A, Gisterek-Grocholska I.   +7 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Prognostic value of <i>MYD88</i>/<i>CXCR4</i> mutation allele fraction in Waldenström macroglobulinemia using a multiplex ddPCR assay. [PDF]

Hemasphere
Thanou E, Kollias I, Kalafati E, Vlachos C, Mavrianou-Koutsoukou N, Theologi O, Sakkou M, Liacos C, Taouxi K, Papadimou A, Chrisostomidou K, Papadopoulos A, Gavriatopoulou M, Terpos E, Lianidou E, Dimopoulos MA, Kastritis E, Markou A, Bagratuni T.   +18 more
europepmc   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

SDF-1 loaded dECM patch improves cardiac function in rats after myocardial ischemia. [PDF]

Stem Cell Res Ther
Zhang J, Lin W, Li Q, Cui S, Bu X, Jiang X, Ma A, Wang T.   +7 more
europepmc   +1 more source