Results 241 to 250 of about 88,749 (308)

Minimal Residual Disease as a Biological Trait: Rethinking Disease Persistence in Hematologic Malignancies

European Journal of Haematology, Volume 117, Issue 2, Page 320-337, August 2026.
ABSTRACT Minimal residual disease (MRD) has emerged as a central biomarker in hematologic malignancies, enabling highly sensitive detection of tumor persistence beyond conventional morphologic assessment and serving as an increasingly important surrogate endpoint in clinical trials.
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +14 more
wiley   +1 more source

Deciphering IFN signaling in gastric cancer: A single-cell and bulk transcriptomic integration reveals CXCR4 as a key immunomodulator and prognostic determinant. [PDF]

Transl Oncol
Song J, Wu F, Wang Y, Chen Q, Zhang Y, Yu H, Chen Y, Jian J.   +7 more
europepmc   +1 more source

FGFR Inhibitor AZD4547 Disrupts Inflammatory CAF Crosstalk With Cancer Cells and Macrophages and Attenuates Metastasis in Pancreatic Cancer

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
This study demonstrates that FGFR‐targeted inhibition by AZD4547 in inflammatory cancer‐associated fibroblasts (iCAFs) intervenes into the tumor–stroma crosstalk. AZD4547 blocks IL‐1α–induced differentiation of pancreatic stellate cells into iCAFs, impairing iCAF‐driven tumor cell differentiation, migration, and M2 macrophage polarization. Consequently,
Ahmed M. R. H. Mostafa, Ahmed G. Hemdan, Franck Assayag, Jai Prakash   +3 more
wiley   +1 more source

Understanding the link between PMN-MDSCs and CXCL8-CXCR1/2 axis in primary myelofibrosis. [PDF]

Front Cell Dev Biol
Campanelli R, Mantovani S, Ramirez C, Tebaldi T, La Gaipa A, Del Fante C, Abbà C, Carolei A, Catarsi P, Barosi G, Massa M, Rosti V.   +11 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, Volume 16, Issue 7, Page 1244-1258, July 2026.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

A CXCR4 targeting peptide delivered by silica nanoparticles eliminates migrating cancer stem cells in pancreatic ductal adenocarcinoma. [PDF]

Sci Rep
Tiwary K, Lahusen A, Inaas S, Beitzinger B, Schmid R, Harms M, Hauff S, Arnold F, Walter K, Alcala S, Hahn S, Heßmann E, Kleger A, Azoitei N, Seufferlein T, Sainz B, Münch J, Lindén M, Hermann PC.   +18 more
europepmc   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, Volume 10, Issue 4, Page 984-994, July 2026.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Overcoming chemotherapy resistance in diffuse large B-cell lymphoma using multifunctional nanocarriers: current advances and clinical challenges. [PDF]

Discov Nano
Li D, Ke X, Hu K.
europepmc   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

High Mobility Group Protein B1 Promotes Interferon Regulatory Factor 1 SUMOylation to Prime Trained Immunity of Circulating Monocytes and Aggravate the Progressive Synovial Inflammation in Knee Osteoarthritis. [PDF]

Research (Wash D C)
Jie L, Mao J, Zhang L, Fu H, Li X, Liao T, Wei Y, Liu D, Du J, Wu P, Yin S, Zhang N, Cao M, Wang P.   +13 more
europepmc   +1 more source