Results 241 to 250 of about 94,110 (297)

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Plasma Cell Selection and Migration in the Establishment of Long-Lived Antibody Responses. [PDF]

Immunol Rev
Ise W, Suzuki K, Kurosaki T.
europepmc   +1 more source

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Spatial transcriptomics reveals injury-responsive compartments and coordinated immune-fibrotic signaling in ANCA-associated renal vasculitis. [PDF]

Front Immunol
Tang Y, Zhu C, Chen S, Chen H, Qian H, Zhang A, Petretto E.   +6 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

CXCR4-targeted PET/CT in early systemic sclerosis-associated interstitial lung disease: a prospective proof-of-concept study of in vivo inflammatory activity. [PDF]

Eur J Nucl Med Mol Imaging
Gernert M, Schmalzing M, Labinsky H, Zhi Y, Strunz PP, Fröhlich M, Hartrampf PE, Buck AK, Werner RA, Serfling SE.   +9 more
europepmc   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

The chemokine network in triple-negative breast cancer: its role in immune microenvironment regulation, and prospects for targeted therapy. [PDF]

Front Immunol
Wang W, Chen L, Guo W, Hu M, Han X, Xia X, Xu W, Ma W.   +7 more
europepmc   +1 more source

Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists. [PDF]

J Am Chem Soc
Zhou J, Liu X, Xu Y, Cruz A, An J, Warshel A, Huang Z.   +6 more
europepmc   +1 more source

Integrated Identification of NAD⁺ Metabolism-Associated Candidate Genes. [PDF]

Mol Neurobiol
Sun S, Hu S, Xu L, Sun M, Wang R, Yuan J, Zhao L.   +6 more
europepmc   +1 more source