A short‐term high‐carbohydrate diet enhances peripheral nerve regeneration more effectively than high‐protein or high‐fat diets by upregulating hemoglobin genes in Schwann cells. Increased hemoglobin promotes Schwann cell proliferation and migration, facilitating nerve repair.
Shiying Li +16 more
wiley +1 more source
CXCR4+ cells in NPC tumor sphere have metastatic potential. [PDF]
Zhu Z +6 more
europepmc +1 more source
Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley +1 more source
CXCR4 mRNA overexpression: an indicator of poor survival and predictor of response to immune checkpoint inhibitors in patients with metastatic colorectal cancer. [PDF]
Gholami S +14 more
europepmc +1 more source
A RANKL<sup>+</sup>/CXCR4<sup>+</sup> B cell population accumulates in bone marrow and causes age-related osteoporosis in mice. [PDF]
Li J +8 more
europepmc +1 more source
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho +7 more
wiley +1 more source
Morphine potentiates HIV infection and receptor expression in 3d brain organoids. [PDF]
Swingler M +5 more
europepmc +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Pharmacological Targeting of CXCR4 Attenuates Sepsis-Induced Intestinal Injury by Suppressing NLRP3/GSDMD-Mediated Pyroptosis. [PDF]
Xu H, Yang S, Li H, Liu D, Gao H.
europepmc +1 more source
ABSTRACT Introduction This study investigates long‐term survival in the Cancer and Anaesthesia (CAN) study, focusing on the potential impact of local anaesthetic infiltration during breast cancer surgery. A positive effect from peritumoral infiltration has recently been suggested.
Mats Enlund +12 more
wiley +1 more source

