Results 251 to 260 of about 94,110 (297)

Endothelial von Hippel-Lindau gene deletion causes abnormal blood and lymphatic vasculature through ectopic activation of the HIF-CXCR4 axis. [PDF]

Development
Li W, Nakayama K, Sato R, Shimada R, Kubota Y, Mukouyama YS.   +5 more
europepmc   +1 more source

Progenitor cells from limbal, conjunctival and oral mucosal biopsies cultivated on silicone hydrogel contact lenses share CD90, CK15, nestin, CXCR4 and SDF-1 niche markers but preserve tissue-specific characteristics and differentiation directions. [PDF]

Front Cell Dev Biol
Zsebik B, Rebenku I, Kemenes G, Nahas A, Vágó M, Lloyd CB, Losonczy G, Vereb G, Takács L.   +8 more
europepmc   +1 more source

Inhibition of high CXCR4 with motixafortide and absence of single-cell MRD predict outcome after AML consolidation.

Blood
Ceran E, Jaramillo Segura S, Merbach AK, Rohde C, Wass M, Schaffrath J, Durruthy-Durruthy R, Arribas-Layton M, Sciambi A, Rieger K, Nogai A, Hänel M, Herbst R, Stölzel F, Röllig C, Jost E, Schlenk RF, Lotze M, Noppeney R, Brandts C, Krug U, Götze KS, Buske S, Florschütz A, Schubert J, Opitz B, Eßeling E, von Witzendorff S, Subklewe M, Kaufmann M, Frickhofen N, Scholz CW, Schäfer-Eckart K, Kunzmann V, Schmidt-Hieber M, Sayer H, Rank A, Hemmati P, Schüler F, Scheller M, Kowoll S, Steighardt J, Edemir B, Ludwig-Kraus B, Müller LP, Edemir S, Vainstein-Haras A, Sorani E, Glicko-Kabir I, Kadosh S, Tavor S, Gromann C, Wienke A, Bauer M, Wickenhauser C, Baldus CD, Platzbecker U, Cerwenka A, Serve H, Bornhäuser M, Junghanß C, Müller-Tidow C.   +61 more
europepmc   +1 more source

RETRACTION: Attenuation of Cartilage Pathogenesis in Post-Traumatic Osteoarthritis (PTOA) in Mice by Blocking the Stromal Derived Factor 1 Receptor (CXCR4) With the Specific Inhibitor, AMD3100. [PDF]

J Orthop Res
europepmc   +1 more source

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CXCR4 and cancer

Pathology International, 2010
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes.
Bungo Furusato
exaly   +4 more sources

CXCR4 signaling in health and disease

Immunology Letters, 2016
Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer.
Antonella Viola, Barbara Molon
exaly   +3 more sources

CXCR4 and Glioblastoma

Anti-Cancer Agents in Medicinal Chemistry, 2015
This article focuses on the possible application of antagonists of the G-protein coupled chemokine receptor, CXCR4, for the treatment of glioblastoma and summarises the evidence for CXCR4 antagonism being a viable therapeutic approach. Particular attention is paid to the role of this receptor in cancer stem cell biology, and the maintenance of CXCR4 ...
openaire   +2 more sources

CXCR4 in Clinical Hematology

2010
Pharmacological manipulation of CXCR4 has proven clinically useful for mobilization of stem and progenitor cells and in several preclinical models of disease. It is a key component in the localization of leukocytes and stem cells. For patients with multiple myeloma and non-Hodgkin's Lymphoma, treatment with plerixafor, an inhibitor of CXCL12 binding to
Gary, Calandra, Gary, Bridger, Simon, Fricker   +2 more
openaire   +2 more sources

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source