Results 271 to 280 of about 88,749 (308)

Nanomaterial-based strategies to overcome sorafenib resistance in hepatocellular carcinoma: from mechanistic insights to translational applications. [PDF]

Front Oncol
Huang J, Huang S, Chen W, Wang S, Zuo Z, Wu X, Deng G.   +6 more
europepmc   +1 more source

Surface Plasmon Resonance as a Potential Diagnostic Tool for the Detection of CXC Chemokine Receptor 4 (CXCR4) on Extracellular Vesicles. [PDF]

Biosensors (Basel)
Verleye K, Noppen S, Boonen A, Yildizhan Y, Van Loy T, Heens C, Vanderhoydonc F, Pinheiro C, Lins PMP, Bronckaers A, Hendrix A, Swinnen JV, Spasic D, Lammertyn J, Pannecouque C, Schols D.   +15 more
europepmc   +1 more source

Genome‐wide association study in 21,271 individuals identifies 9 novel loci associated with circulating CD34+ hematopoietic stem and progenitor cell levels

HemaSphere, Volume 10, Issue 7, July 2026.
Yuwen Xie, Antton Lamarca, Caterina Cafaro, Gudmar Thorleifsson, Ludvig Ekdahl, Daniela Torres Di Bello, Zain Ali, Yen La, Lilja Stefansdottir, Alex Antill, Maroulio Pertesi, Maria Laura Mahecha Escobar, Magnús K. Magnússon, Simon N. Stacey, Kari Stefansson, Ingileif Jonsdottir, Göran Karlsson, Thorunn Olafsdottir, Unnur Thorsteinsdottir, Aitzkoa Lopez de Lapuente Portilla, Björn Nilsson   +20 more
wiley   +1 more source

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CXCR4 signaling in health and disease

Immunology Letters, 2016
Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer.
Antonella Viola, Barbara Molon
exaly   +3 more sources

CXCR4 in Clinical Hematology

2010
Pharmacological manipulation of CXCR4 has proven clinically useful for mobilization of stem and progenitor cells and in several preclinical models of disease. It is a key component in the localization of leukocytes and stem cells. For patients with multiple myeloma and non-Hodgkin's Lymphoma, treatment with plerixafor, an inhibitor of CXCL12 binding to
Gary, Calandra, Gary, Bridger, Simon, Fricker   +2 more
openaire   +2 more sources

CXCR4 and Glioblastoma

Anti-Cancer Agents in Medicinal Chemistry, 2015
This article focuses on the possible application of antagonists of the G-protein coupled chemokine receptor, CXCR4, for the treatment of glioblastoma and summarises the evidence for CXCR4 antagonism being a viable therapeutic approach. Particular attention is paid to the role of this receptor in cancer stem cell biology, and the maintenance of CXCR4 ...
openaire   +2 more sources

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source

The CXCR4/CXCL12 axis in endometrial cancer

Clinical & Experimental Metastasis, 2009
Chemokines and their receptors seem to act as important regulators of the metastatic cascade. CXCL12 and its receptor CXCR4 were shown to be involved in human cancer progression. There is increasing evidences suggesting that the expression of CXCR4 in human cancers is correlated with poor patient prognosis and that CXCR4 neutralization can prevent ...
GELMINI, STEFANIA, MANGONI, MONICA, CASTIGLIONE, FRANCESCA, Beltrami C, Pieralli A, Andersson KL, FAMBRINI, MASSIMILIANO, TADDEI, GIAN LUIGI, SERIO, MARIO, ORLANDO, CLAUDIO   +9 more
openaire   +3 more sources

CXCR4, Inhibitors and Mechanisms of Action

Chemical Biology & Drug Design, 2008
In this review, the author discusses recent advances in anti‐HIV inhibitors, targeting CXCR4, including natural and modified chemokines, peptides and organic compounds, their mechanisms of action, and the molecular process of virus invasion of immune cells.
openaire   +2 more sources

Evaluation of Human and Rhesus CD34+CXCR4+ and CD34+CXCR4- Subpopulations

Blood, 2011
Abstract Abstract 1007 CXCR4 is an α-chemokine receptor specific for the ligand stromal-derived-factor-1 (SDF-1). CXCR4 is expressed on several cell types, including CD34+ cells. In this study, we sought to evaluate the difference between subpopulations of human and rhesus CD34+ cells that express CXCR4. Rhesus CD34+ cells
Naoya Uchida, Yu Tian, Ping Jin, Aylin C. Bonifacino, Mark E. Metzger, David Stroncek, John F. Tisdale, Robert E. Donahue   +7 more
openaire   +1 more source