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Evaluation of Human and Rhesus CD34+CXCR4+ and CD34+CXCR4- Subpopulations
Blood, 2011Abstract Abstract 1007 CXCR4 is an α-chemokine receptor specific for the ligand stromal-derived-factor-1 (SDF-1). CXCR4 is expressed on several cell types, including CD34+ cells. In this study, we sought to evaluate the difference between subpopulations of human and rhesus CD34+ cells that express CXCR4. Rhesus CD34+ cells
Naoya Uchida +7 more
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CXCR4 Imaging in Multiple Myeloma
2019The C–X–C chemokine receptor 4 (CXCR4) and its natural ligand CXCL12 are key factors in the process of cell migration, homing of hematopoietic stem cells to the bone marrow, and represent important mediators of angiogenesis and cell proliferation. In many pathological conditions, such as multiple myeloma, high CXCR4 expression is frequently observed ...
Morales, M. I. +2 more
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HIV coreceptor CXCR4 antagonists
Current Opinion in HIV and AIDS, 2006Increases in HIV resistance towards approved antiviral drugs have made it necessary to develop new and potent antiviral drugs with preferably a novel mode of action.Entry inhibitors constitute a new class of drugs to treat infection by HIV-1. The first member of this class, enfuvirtide, previously known as T-20 and targeting gp41, has now been licensed
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CXCR4, Inhibitors and Mechanisms of Action
Chemical Biology & Drug Design, 2008In this review, the author discusses recent advances in anti‐HIV inhibitors, targeting CXCR4, including natural and modified chemokines, peptides and organic compounds, their mechanisms of action, and the molecular process of virus invasion of immune cells.
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CMTM4 is a novel interactor of CXCR4 and regulator of CXCL12/CXCR4 signaling
Ο CXCR4 είναι ένας υποδοχέας χημειοκινών που ανήκει στην υπεροικογένεια των υποδοχέων που συνδέονται με τις πρωτεΐνες G (G protein-coupled receptors). Ο φυσικός συνδέτης του CXCR4 είναι η χημειοκίνη CXCL12. Η αλληλεπίδραση μεταξύ του υποδοχέα και του συνδέτη του ενεργοποιεί πολυάριθμα σηματοδοτικά μονοπάτια, ελέγχοντας τη μετανάστευση, την επιβίωση ...openaire +1 more source
CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis
Ageing Research Reviews, 2023Yang Yang, Wangrui Lei, Ran Tang
exaly
The significance of cancer cell expression of the chemokine receptor CXCR4
Seminars in Cancer Biology, 2004Fran Balkwill
exaly