Results 261 to 270 of about 88,749 (308)

CXCR4, CXCR7 and PBRM1 are responsible for everolimus and cabozantinib resistance in human renal cancer cells. [PDF]

Cell Death Discov
Auletta F, Ieranò C, Di Febbraro DG, Bello AM, Rea G, Napolitano M, Galdiero F, Guardascione G, Trotta AM, Santagata S, Vetrei C, Di Maiolo G, Russo D, Spina A, D'Alterio C, Portella L, Ascrizzi S, Scaglione GL, Tassone P, Di Martino MT, Scala S.   +20 more
europepmc   +1 more source

The LAV‐BPIFB4‐Platelet‐CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Elena Ciaglia, Roberta Maria Esposito, Valentina Lopardo, Francesco Montella, Cristina Basile, Roberta Longo, Anna Maciag, Giuseppe Rescigno, Antonio Damato, Francesco Del Plato, Alfonso Finizio, Carmine Vecchione, Albino Carrizzo, Annibale Alessandro Puca   +13 more
wiley   +1 more source

Signaling pathway mechanisms in pancreatic ductal adenocarcinoma tumor microenvironment and emerging targeting strategies for improved prognosis. [PDF]

Oncol Rev
Akinsipe T, Odewumi CO, Latinwo L, Aghimien OO, Musa MA, Igbinoba PO, Simons AL, Aghimien MO.   +7 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. [PDF]

Int J Mol Med
Sun Z, Wang C, Shi C, Sun F, Xu X, Qian W, Nie S, Han X.   +7 more
europepmc   +1 more source

Plasma Protein Analysis for Biomarker Discovery in Lung Cancer Treated With Atezolizumab Combination Therapy in J‐TAIL‐2

Cancer Science, Volume 117, Issue 7, Page 1948-1960, July 2026.
BLURB FOR ETOC: The J‐TAIL‐2 study (NCT04501497) evaluated the efficacy and safety of atezolizumab, an anti‐programmed death‐ligand 1, plus chemotherapy in patients with non‐small cell lung cancer (NSCLC) and extensive‐stage small cell lung cancer (ES‐SCLC) in real‐world settings.
Yasushi Goto, Makoto Nishio, Kadoaki Ohashi, Atsushi Osoegawa, Eiki Kikuchi, Hideharu Kimura, Junichi Shimizu, Eisaku Miyauchi, Hiroshige Yoshioka, Ichiro Yoshino, Toshihiro Misumi, Yasutaka Watanabe, Nobuyuki Katakami, Akira Kisohara, Masafumi Yamaguchi, Hirotaka Kuroki, Masamichi Sugimoto, Hisao Ashimura, Misa Tanaka, Akihiko Gemma   +19 more
wiley   +1 more source

Identification of tolerogenic dendritic cells-related prognostic biomarkers in Wilms tumor via machine learning integration. [PDF]

Discov Oncol
Sun X, Gao Y, Meng K, Wang Y, Wang B.
europepmc   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, Volume 293, Issue 13, Page 3991-4013, July 2026.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

hucMSCs alleviate LPS-induced endothelial glycocalyx damage by secreting Cxcl12 to activate CXCR4. [PDF]

Stem Cell Res Ther
Cui J, Peng Z, Chen Y, Liu W, Chen Q, Wang X, Wang T, Huang X, Sun T.   +8 more
europepmc   +1 more source

Ovarian hormones and high‐fat diet duration distinctively modulate hypothalamic chemokine profile

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Alexia Guimaraes Batista Augusto, Giovanna Ariozi dos Santos, Igor Vinicius Sousa Cavalheiro, Vinicius Stefanini Mantovan, Larissa Silva Bergantini, Nicolly Porto Marin, Ester dos Santos Alves, Licio Augusto Velloso, Natalia Ferreira Mendes   +8 more
wiley   +1 more source