Results 301 to 310 of about 157,119 (339)

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation. [PDF]

Front Mol Biosci
Sun X, Yang H, Leng Z, Zhang W, Jiang Z, Liu H.   +5 more
europepmc   +1 more source

Single-Cell Mapping Reveals MIF-Centered Immunoregulatory Networks in Colorectal Cancer. [PDF]

Int J Mol Sci
Gkoris M, Georgakopoulos-Soares I, Zaravinos A.   +2 more
europepmc   +1 more source

Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases. [PDF]

Arthritis Res Ther
Ruths L, de Hesselle H, Haußner F, Albers S, Harms M, Freitag T, Münch J, Riegger J.   +7 more
europepmc   +1 more source

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CXCL12/CXCR4: an amazing challenge and opportunity in the fight against fibrosis.

Ageing Research Reviews, 2022
Fibrosis is a pathological process caused by abnormal wound healing response, which often leads to excessive deposition of extracellular matrix, distortion of organ architecture, and loss of organ function.
Xue Wu, Lu-jing Qian, Huadong Zhao, Wangrui Lei, Yanqing Liu, Xiaoling Xu, Jiawen Li, Zhi Yang, Du Wang, Yuchen Zhang, Yan Zhang, Ran Tang, Yang Yang, Ye Tian   +13 more
semanticscholar   +1 more source

Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages.

Cancer Letters, 2020
Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found
Dong Wang, Xiaohui Wang, Mahan Si, Juan Yang, Shi-Yue Sun, Haochen Wu, S. Cui, Xian-Jun Qu, Xinfeng Yu   +8 more
semanticscholar   +1 more source

CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis.

Life Science, 2020
Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis.
K. Mortezaee
semanticscholar   +1 more source

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source