Cholesterol oxidase treatment impairs CXCR4-mediated T cell migration. [PDF]
Gardeta SR +7 more
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Chemokine Receptors in Peripheral Blood Mononuclear Cells as Predictive Biomarkers for Immunotherapy Efficacy in Non-Small Cell Lung Cancer. [PDF]
Galera P +11 more
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G protein-coupled receptors in prostate cancer: research progress and therapeutic targets. [PDF]
Xiong W, Zhou B, Shi J, Ni D, Xiong Z.
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Single-cell transcriptomic profiling reveals aberrant CD4⁺ naive T cell differentiation driving immune activation in Behçet's uveitis. [PDF]
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Chemokines and their receptors in oral squamous cell carcinoma: mechanisms, clinical significance, and therapeutic implications. [PDF]
Li D +6 more
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Determination of conformations adopted by CXCR4 and CCR5 at the cell surface
Sunniva Yngvil Dyrhaug
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Correction to "LncRNA UCA1 Promotes the Progression of AML by Upregulating the Expression of CXCR4 and CYP1B1 by Affecting the Stability of METTL14". [PDF]
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Blood, 2004Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
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This article focuses on the possible application of antagonists of the G-protein coupled chemokine receptor, CXCR4, for the treatment of glioblastoma and summarises the evidence for CXCR4 antagonism being a viable therapeutic approach. Particular attention is paid to the role of this receptor in cancer stem cell biology, and the maintenance of CXCR4 ...
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