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Low- or No-Energy Sweeteners and Body Weight Management: Dissecting a "Minor" Effect. [PDF]

Obes Rev
ABSTRACT Nonnutritive sweeteners were introduced on the market over a century ago to displace the calories of added sugars in foods and beverages and, therefore, facilitate weight loss. In spite of their widespread use, obesity has reached epidemic proportions. The present paper addresses this apparent paradox. Low‐ or no‐energy sweeteners (LNES) are a
Bellisle F.
europepmc +2 more sources

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study provides a novel molecular perspective on the role of AS in ADs development. We identified a positive association between artificially sweetened cereal intake and ADs risk and revealed multiple pathogenic mechanisms involving apoptosis, inflammatory signaling, immune activation, and gut microbiota dysbiosis.
Yupei Liu +6 more
wiley +1 more source

Monitoring Population Exposure to Low‐ and No‐Calorie Sweeteners via Pooled Urine Analysis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The graphical abstract illustrates trends in low‐ and no‐calorie sweeteners exposure across the Australian population. It highlights differences between males and females across six age groups, as well as variation across five remoteness categories. An example biomarker, saccharin, is shown with concentrations plotted by age group, demonstrating how ...
Nicole S. Schröter +6 more
wiley +1 more source

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on Hereditary Fructose Intolerance (HFI), or aldolase B deficiency, and fructose malabsorption (intestinal fructose intolerance)

Food Risk Assess Europe, Volume 4, Issue 2, April 2026.
Abstract Hereditary Fructose Intolerance (HFI), also known as aldolase B deficiency, is an inherited metabolic disorder caused by the deficiency of that enzyme, which participates in the fructose metabolism in the liver, kidneys and small intestine. Aldolase B deficiency brings about the accumulation of fructose‐1‐phosphate in these organs, which can ...
Araceli Díaz Perales +6 more
wiley +1 more source

Effect of Miracle Berry on Taste Modification Properties Among Adults Living in Australia: A Multi‐Phase Study Protocol

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Miracle Berry (Synsepalum dulcificum) (MB), through its active glycoprotein miraculin, transforms sour tastes into sweet ones. This four‐phase quasi‐experimental protocol involves healthy‐weight (Phases 1 and 2) and overweight/obese (Phases 3 and 4) adults to examine the taste modification properties of MB. The phases progress from testing MB's effects
Getahun Fentaw Mulaw +5 more
wiley +1 more source

Gummies as a Novel Approach to Valorize Rainbow Trout Wastes

Journal of Food Science, Volume 91, Issue 3, March 2026.
ABSTRACT In this study, a potential waste management strategy was developed for the evaluation of marine and freshwater fish waste, which is chemically very similar. To this end, an unmet need has been addressed by converting by‐products from rainbow trout, a cold‐water fish, into functional and nutritious ingredients.
Gonca Alak +8 more
wiley +1 more source

Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Chewable softgels are a patient‐preferred alternative to conventional oral forms, offering pleasant taste, fast onset, and suitability for children or patients with swallowing difficulties. However, they present relevant challenges in their formulation: the shell must balance chewability, machinability, and stability, while the fill must mask the ...
Almudena Naharros‐Molinero +3 more
wiley +1 more source

Re‐evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The present opinion deals with the re‐evaluation of sucralose (E 955) as food additive and with the safety of a proposed extension of use in food category (FC) 7.2 ‘Fine bakery wares’. Based on the available data, no safety concerns arose for genotoxicity of sucralose (E 955) and its impurities and degradation products.
EFSA Panel on Food Additives and Flavourings (FAF) +36 more
wiley +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, Volume 15, Issue 12, Page 1955-1962, December 2025.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source

sweetening agents
humans
animals

united states
rats
united states food and drug administration

female
cyclohexanes
mice