Results 1 to 10 of about 121,650 (304)

Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis [PDF]

Frontiers in Physiology, 2019
3′,5′-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling.
Vladimir Dikolayev, Vladimir Dikolayev, Turlybek Tuganbekov, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +4 more
doaj   +4 more sources

Downregulation of cyclic adenosine monophosphate levels in leukocytes of hibernating captive black bears is similar to reported cyclic adenosine monophosphate findings in major depressive disorder [PDF]

Frontiers in Psychiatry, 2023
IntroductionCyclic adenosine monophosphate (cAMP) levels in the lymphoblasts and leukocytes of patients with major depressive disorder (MDD) have been reported to be downregulated compared to in controls.
John A. Tsiouris, John A. Tsiouris, Michael Flory   +2 more
doaj   +2 more sources

Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway [PDF]

Nanomaterials, 2021
Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi   +2 more
doaj   +2 more sources

Cyclic adenosine monophosphate potentiates immune checkpoint blockade therapy in acute myeloid leukemia. [PDF]

Clin Transl Med, 2023
Mao P, Feng W, Zhang Z, Huang C, Zhou S, Zhao Z, Mu Y, Zhao AY, Wang L, Li F, Zhao AZ.   +10 more
europepmc   +2 more sources

Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus [PDF]

Brain and Behavior, 2019
Background Fear renewal, the context‐specific relapse of a conditioned fear after extinction, is a widely pursued model of post‐traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood.
Yan-Wei Shi, Bu-Fang Fan, Li Xue, Xiao-Guang Wang, Xue-Ling Ou   +4 more
doaj   +2 more sources

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

Frontiers in Microbiology, 2021
Research on nucleotide-based second messengers began in 1956 with the discovery of cyclic adenosine monophosphate (3′,5′-cAMP) by Earl Wilbur Sutherland and his co-workers.
Frank Braun, Alejandra Recalde, Heike Bähre, Roland Seifert, Sonja-Verena Albers   +4 more
doaj   +1 more source

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Nature Communications, 2021
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair ...
Daipayan Banerjee, Kurt Langberg, Salar Abbas, Eric Odermatt, Praveen Yerramothu, Martin Volaric, Matthew A. Reidenbach, Kathy J. Krentz, C. Dustin Rubinstein, David L. Brautigan, Tarek Abbas, Bradley D. Gelfand, Jayakrishna Ambati, Nagaraj Kerur   +13 more
doaj   +1 more source

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing

Frontiers in Immunology, 2021
Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membrane and cytosolic
Eloi R. Verrier, Christelle Langevin
doaj   +1 more source

Components and Pharmacodynamical Mechanism of Yinfupian Based on Liquid Chromatography-Mass Spectrometry and Proteomics Analyses

Frontiers in Pharmacology, 2021
Objective: According to the treatment records of Yang deficiency syndrome (YDS) with characteristic decoction pieces of lateral root of Aconitum carmichaelii—Yinfupian (YF) in traditional Chinese medicine prepare school, known as “Jianchangbang”. The aim
Heng-li Tong, Hao Chen, Fei-peng Gong, Ling-yun Zhong, Jing Zhu, Song-hong Yang   +5 more
doaj   +1 more source

The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats

Journal of Ginseng Research, 2017
Background: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism.
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou   +3 more
doaj   +1 more source