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ABSTRACT Double‐stranded DNA coming from, for example, viruses, bacteria, or apoptotic cells is recognized by the cGAS‐STING signaling pathway comprising the cyclic GMP‐AMP synthase (cGAS) and the stimulator of interferon genes (STING) receptors. The pathway induces type I interferon response and activates transcription of interferon‐stimulated genes ...
András Harazin +9 more
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Ren-jye Ho Zhou Shu Lou Ailin Ye Zhiwen Bai Huqun Yao Guanzhen Chen Yuzhen Xu Rongkun Xue Zuohong Cheng Lanying Zhu Guangjin Zheng Xiaozhao
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Cyclic adenosine monophosphate in bacteria.
Science (New York, N.Y.), 1970Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins.
I, Pastan, R, Perlman
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Stimulation of erythropoiesis by cyclic adenosine monophosphate
Life Sciences, 1971Abstract CYCLIC AMP stimulated the incorporation of radioiron by the red blood cells in polycythemic mice. This effect was potentiated by prior incubation of cyclic AMP with dialyzed rat serum and was partially abolished in vivo , but not in vitro , by anti-erythropoietin.
A S, Gidari, E D, Zanjani, A S, Gordon
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Cyclic Adenosine Monophosphate: Function in Photoreceptors
Science, 1971Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along
W H, Miller, R E, Gorman, M W, Bitensky
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Cyclic adenosine monophosphate and the development of polysphondylium
Journal of Cell Science, 1976ABSTRACT Centre formation in Polysphondylium violaceum is delayed for 2 h on buffered agar containing 10−3 M c-AMP, and for up to 22 h on unbuffered agar with the same c-AMP concentration. With ambient c-AMP concentrations as low as 10−8 M, P. pallidum forms numerous, small, atypical aggregates which do not fruit.
M E, Jones, A, Robertson
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Distribution of Cyclic Adenosine Monophosphate in Rat Brain
Archives of Neurology, 1971Cyclic 3',5'-adenosine monophosphate (AMP) was assayed by converting it enzymatically to adenosine triphosphate (ATP) with phosphodiesterase, myokinase, and pyruvate kinase. Adenosine triphosphate was measured in a liquid scintillation spectrometer from the photons emitted when ATP serves as a substrate of the firefly luciferin-luciferase system.
M S, Ebadi, B, Weiss, E, Costa
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