Results 111 to 120 of about 131,836 (300)

Mutations in the cyclic AMP binding site of the cyclic AMP receptor protein of Escherichia coli [PDF]

, 1988
Mutants in the cyclic AMP binding site of the cyclic AMP receptor protein (CRP) of Escherichia coli have been constructed by oligonucleotide-directed mutagenesis.
Rodica Sandulache, Silvia Gartner, Angela M. Gronenborn, G. Marius Clore   +3 more
core  

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. [PDF]

, 2012
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3.
Ouyang, Songying, Zhiqiang Zhang, Iyer, Shankar S, Schenk, Mirjam, Liu, Zhi-Jie, Zhong, Wenwan, Parvatiyar, Kislay, Mirjam Schenk, Yong-jun Liu, Zaver, Shivam A, Kislay Parvatiyar, Liu, Yong-jun, Genhong Cheng, Jiang, Yan, Zeng, Shang, Modlin, Robert L, Songying Ouyang, Yan Jiang, Wenwan Zhong, Cheng, Genhong, Teles, Rosane M, Robert L Modlin, Zhi-Jie Liu, Shivam A Zaver, Shang Zeng, Rosane M Teles, Zhang, Zhiqiang, Shankar S Iyer   +27 more
core   +1 more source

Molecular Dynamics Studies of Shape Memory Polymers: From Bead–Spring Models to Atomistic Simulations

Advanced Engineering Materials, EarlyView.
Coarse‐grained (left) and atomistic (right) models of the shape memory polymer ESTANE ETE 75DT3 are shown schematically. The two representations bridge molecular detail and mesoscopic description. Both models capture shape memory behavior, linking segmental mobility and conformational relaxation of anisotropic chains to macroscopic recovery, and ...
Fathollah Varnik
wiley   +1 more source

Structural and functional studies on nucleotide binding to AMP-activated protein kinase

, 2010
AMP-activated protein kinase (AMPK) is an enzyme that senses and regulates cellular energy balance thus playing a key role in homeostasis. As such it is a target for treatment of metabolic disorders such as type II diabetes.
Saiu, P.
core  

Experimental Characterization and Constitutive Modeling of the Effect of Prior Inelastic Strain on the Viscoplastic Behavior of AD730 at 700 °C

Advanced Engineering Materials, EarlyView.
This study shows that superalloys used in aircraft engine disks become much more prone to deformation at high temperatures if they have been strained during manufacturing. This effect increases with the level of prior strain but eventually reaches a limit.
Fabio Machado Alves da Fonseca, Patrick Villechaise, Malik Durand, Arnaud Longuet, Florent Coudon, Loïc Signor, Julien De Jaeger, Dominique Eyidi, Nathalie Bozzolo, Jonathan Cormier   +9 more
wiley   +1 more source

Low Cycle Repetitive Loading of Ti‐6Al‐4V‐Epoxy Composite Lattice Structures for Enhanced Energy Dissipation and Damage Tolerance

Advanced Engineering Materials, EarlyView.
Composite Ti–6Al–4V–epoxy lattice structures are additively manufactured and epoxy infiltrated for cyclic loading. At low lattice volume fractions, hybridization produces synergistic gains in stiffness and energy dissipation. At higher volume fractions, synergy diminishes, although composites still exceed metallic lattices in specific energy ...
Joey Tallon, Jordan Noronha, Justin Dirrenberger, Andrey Molotnikov   +3 more
wiley   +1 more source

Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases

, 1978
The effects of various agents on the newly identified cyclic CMP phosphodiesterase (C-PDE) in crude extracts of a number of rat tissues and on the enzyme partially purified from the rat liver were examined. Papaverine and 1-methyl-3-isobutylxanthine were
Helfman, D M, Kuo, J F, Brackett, N L, Shoji, M   +3 more
core  

Microstructure Reconstruction in Battery Electrodes Using Machine Learning Based on Low‐Voltage Focused Ion Beam–Scanning Electron Microscopy Tomography Images

Advanced Engineering Materials, EarlyView.
Low‐voltage FIB‐SEM tomography combined with a image preprocessing pipeline improves phase contrast and enables reliable machine‐learning segmentation of conductive networks in lithium‐ion battery electrodes. Structural descriptors are extracted from segmented images, done semimanually and automated, and compared.
Lisa Beran, Vincent Nebel, Dominik Perius, Kshitij Kumar, Yannis Heim, Laura Bies, Tobias Kraus   +6 more
wiley   +1 more source

Actions of Cyclic AMP and Dibutyryl Cyclic AMP on the Electricl and Mechanical Activities of the Cat Small Intestine [PDF]

, 1975
Cyclic AMP and dibutyeyl cyclic AMP produced the inhibitory action on the spike activity and contraction of the cat small intestine Beta-stimulants also exhibited the inhibitory action.
Ohkawa, Hiromichi
core  

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source