Results 61 to 70 of about 1,140,604 (331)
Role of cyclic AMP in the control of cell-specific gene expression [PDF]
, 1993 Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
1H-Pyrazol-2-ium hydrogen oxalate
Acta Crystallographica Section E, 2012 In the title compound, C3H5N2+·C2HO4−, the anions form centrosymmetric dimers through cyclic O—H...O hydrogen-bonding associations [graph set R22(10)].
Chun-Hua Yu, Run-Qiang Zhu
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
mSpherecAMP plays an important role as a second messenger in the stage transition of various protozoan parasites. This signaling pathway relies on multiple effectors, such as protein kinase A (PKA), exchange protein activated by cAMP, and cAMP-response element ...
Han-Wei Shih +2 more
doaj +1 more source
Acta Crystallographica Section E, 2010 The title compound, CH6N3+·C7H4NO4−, an anhydrous guanidinium salt, shows a N—H...O hydrogen-bond network in which the guanidinium cation is involved in three cyclic R21(6) hydrogen-bonding associations with separate ...
Graham Smith, Urs D. Wermuth
doaj +1 more source
The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]
, 1980 Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J +3 more
core
Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]
, 2015 Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core +1 more source
Cyclic AMP and the induction of eukaryotic gene transcription.
Journal of Biological Chemistry, 1988 L'AMPc coordonne differentes voies metaboliques allant de la degradation du glycogene dans le foie des mammiferes a la synthese d'enzymes specifiques impliquees dans le metabolisme energetique d'Escherichia coli.
J. William +6 more
semanticscholar +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source