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Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients. [PDF]
Neefjes M+10 more
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Impaired synaptic transmission and long-term potentiation in severe combined immunodeficient (SCID) mice. [PDF]
Lupacchini L+4 more
europepmc +1 more source
A novel antibacterial hydrogel containing aminophylline as a versatile platform for neural differentiation of hWJMSCs through the CREB pathway. [PDF]
Seyedi Jasbi AS+4 more
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Cyclic AMP response element-binding protein and depression
Expert Review of Neurotherapeutics, 2002Depression is one of the most common and most devastating psychiatric disorders. Although a variety of treatment strategies is available, a major problem in its therapy consists of the unpredictability of the drug response. Furthermore, most antidepressant drugs, which usually increase 5-HT and norepinephrine levels in the synaptic cleft, are likely to
Fritz A. Henn+2 more
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Cyclic AMP‐Responsive Element Binding Protein in Brain Mitochondria
Journal of Neurochemistry, 1999Abstract: Cyclic AMP‐responsive element binding protein (CREB) is critically involved in many important brain functions, including the formation of long‐term memory. CREB is the best characterized member of a family of transcription factors (CREB/ATF family) recognized to be important nuclear targets for intracellular signal transduction systems. Here
Margarita Lopez+7 more
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Presence of a Cyclic AMP Response Element‐Binding Protein in Oligodendrocytes
Journal of Neurochemistry, 1993Abstract: Several lines of evidence indicate that cyclic AMP (cAMP) induces oligodendrocyte differentiation. However, the mechanism(s) of this stimulation remains unknown. Because in several cell types the transcriptional activity of various cAMP‐responsive genes is regulated through a cisacting DNA sequence known as cAMP response element (CRE), we ...
Carmen Sato-Bigbee, Robert K. Yu
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Role of cyclic AMP response element binding protein in human leukemias
Cancer, 2005AbstractAcute myeloid leukemia (AML) in adults has a 20% 5‐year disease‐free survival despite treatment with aggressive cytotoxic chemotherapy. Previous work from our laboratory demonstrated that the majority of patients with acute lymphoid and myeloid leukemia overexpress CREB in the bone marrow.
Deepa B. Shankar+2 more
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