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Cyclic AMP response element-binding protein and depression
Expert Review of Neurotherapeutics, 2002Depression is one of the most common and most devastating psychiatric disorders. Although a variety of treatment strategies is available, a major problem in its therapy consists of the unpredictability of the drug response. Furthermore, most antidepressant drugs, which usually increase 5-HT and norepinephrine levels in the synaptic cleft, are likely to
Johannes, Thome +2 more
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Cyclic AMP‐Responsive Element Binding Protein in Brain Mitochondria
Journal of Neurochemistry, 1999Abstract: Cyclic AMP‐responsive element binding protein (CREB) is critically involved in many important brain functions, including the formation of long‐term memory. CREB is the best characterized member of a family of transcription factors (CREB/ATF family) recognized to be important nuclear targets for intracellular signal transduction systems. Here
M, Cammarota +7 more
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Presence of a Cyclic AMP Response Element‐Binding Protein in Oligodendrocytes
Journal of Neurochemistry, 1993Abstract: Several lines of evidence indicate that cyclic AMP (cAMP) induces oligodendrocyte differentiation. However, the mechanism(s) of this stimulation remains unknown. Because in several cell types the transcriptional activity of various cAMP‐responsive genes is regulated through a cisacting DNA sequence known as cAMP response element (CRE), we ...
C, Sato-Bigbee, R K, Yu
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The Journal of Pharmacology and Experimental Therapeutics, 1996
The purpose of the present study was to track the acute effects of ethanol on the cerebellar adenylyl cyclase cascade from membrane to nucleus and to determine how this important signaling pathway neuroadapts during chronic ethanol exposure. An acute ethanol challenge increased cyclic AMP content and protein kinase A activity by 80% compared to control
X, Yang, A M, Diehl, G S, Wand
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The purpose of the present study was to track the acute effects of ethanol on the cerebellar adenylyl cyclase cascade from membrane to nucleus and to determine how this important signaling pathway neuroadapts during chronic ethanol exposure. An acute ethanol challenge increased cyclic AMP content and protein kinase A activity by 80% compared to control
X, Yang, A M, Diehl, G S, Wand
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Isoforms of cyclic AMP response element binding proteins in Drosophila S2 cells
Biochemical and Biophysical Research Communications, 2004Activation or inhibition of the cyclic AMP (cAMP)-protein kinase A (PKA) pathway can ultimately regulate the transcription of a variety of genes. In vertebrates, the best characterized nuclear targets of PKA are the 'cAMP response element' (CRE) binding proteins (CREB).
Jeroen, Poels +7 more
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Molecular Pharmacology, 1995
Clinical observations agree that antidepressant drugs are effective only after a lag phase of 1-3 weeks. This delay could be explained at the molecular level by an action on gene transcription. Transcription of many genes is directed by the cAMP/Ca(2+)-responsive element (CRE) and its cognate transcription factor CRE-binding protein (CREB).
M, Schwaninger +4 more
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Clinical observations agree that antidepressant drugs are effective only after a lag phase of 1-3 weeks. This delay could be explained at the molecular level by an action on gene transcription. Transcription of many genes is directed by the cAMP/Ca(2+)-responsive element (CRE) and its cognate transcription factor CRE-binding protein (CREB).
M, Schwaninger +4 more
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Estrogen Modulation of the Cyclic AMP Response Element-Binding Protein Pathway
Neuroendocrinology, 2001Actions of estrogen include mechanisms leading to alterations in gene transcription that may be independent of nuclear estrogen receptors, as well as those involving direct action of the estrogen receptor on the genome. Also, the influence of estrogen in the brain appears to extend well beyond areas associated with reproduction and may include ...
Luke Carlstrom +4 more
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