Results 251 to 260 of about 64,980 (302)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential. [PDF]

J Med Virol
Lee H, Cho H, Gack MU.
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer. [PDF]

Front Toxicol
Cooper RL, Simpkins JW, Breckenridge C.
europepmc   +1 more source

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies. [PDF]

J Anim Sci Biotechnol
Shen T, Li M, Sun X, Deng Z, Pitts H, Nolan D, Loor JJ, Xu C.   +7 more
europepmc   +1 more source

Live-cell imaging reveals decreased cAMP in a PFE-associated c.1050-3C>G PTH1R cell model. [PDF]

J Mol Med (Berl)
Marnet K, Subramanian H, Wiesler M, Borst A, Liedtke D, Pattappa G, Docheva D, Nikolaev VO, Stellzig-Eisenhauer A, Eigenthaler M, Herrmann M.   +10 more
europepmc   +1 more source

Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts. [PDF]

J Mol Cell Cardiol
Hulsurkar MM, Ong I, Keefe JA, Abu-Taha IH, Dobrev D, Wehrens XHT.   +5 more
europepmc   +1 more source

cGAS-STING signaling pathway as a therapeutic target in human diseases. [PDF]

Chin Med J (Engl)
Xiao Y, Ma Y, Zhao J, Zhang X, Gan C, Gao J, Huang Z.   +6 more
europepmc   +1 more source

Trends in Inhibitors, Structural Modifications, and Structure-Function Relationships of Phosphodiesterase 4: A Review. [PDF]

Biomolecules
Sánchez-Belmonte A, Matencio A, Conesa I, Vidal-Sánchez FJ, Trotta F, López-Nicolás JM.   +5 more
europepmc   +1 more source