Results 261 to 270 of about 29,900 (296)

Regulation of Phosphorylation of Cyclic AMP Response Element-Binding Protein by Paroxetine Treatments

Clinical Neuropharmacology, 2000
The present study was undertaken to examine the effect of paroxetine, a selective serotonin reuptake inhibitor, on the phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) in the rat brain. Single administration of paroxetine significantly induces the phosphorylation of CREB in the rat frontal cortex and ...
S, Morinobu, D S, Russel, S, Sugawara, M, Takahashi, K, Fujimaki   +4 more
openaire   +2 more sources

Transcriptional Activation of the Proopiomelanocortin Gene by Cyclic AMP-responsive Element Binding Protein

Pituitary, 1998
The proopiomelanocortin (POMC) gene expressed in corticotrophs of the anterior pituitary encodes several biologically active peptides and is primarily under the positive control of hypophysiotropic factors (e.g. corticotropin releasing hormone). Using AtT20 cells as a model, we show that these factors increase levels of POMC primary RNA transcripts ...
A L, Boutillier, C, Gaiddon, D, Lorang, J L, Roberts, J P, Loeffler   +4 more
openaire   +2 more sources

miR-34b Targets Cyclic AMP–Responsive Element Binding Protein in Acute Myeloid Leukemia

Cancer Research, 2009
Abstract The cyclic AMP–responsive element binding protein (CREB) is documented to be overexpressed in leukemia, but the underlying mechanism remains unknown. Here, microRNAs (miRNA), which act as negative regulators of gene expression principally through translational repression, are investigated for the mediation of high CREB protein ...
PIGAZZI, MARTINA, MANARA, ELENA, BARON E., BASSO, GIUSEPPE   +3 more
openaire   +3 more sources

Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior

Neuroscience, 2005
Analysis of mice with targeted disruptions of fosB or the gene encoding dopamine beta-hydroxylase suggests that FosB and adrenergic signaling play critical roles in maternal nurturing behavior. The majority of neonates born to null females from either mutation fail to thrive, and virgin mutant females of both lines exhibit impaired pup retrieval ...
S-H, Jin, J A, Blendy, S A, Thomas
openaire   +2 more sources

Schwann cells stimulated by axolemma-enriched fractions express cyclic AMP responsive element binding protein

Journal of Neuroscience Research, 1996
Both axolemma-enriched fractions (AEF) and cyclic AMP have been shown to regulate the proliferation and differentiation of cultured primary Schwann cells (SC). We have evaluated the role of CREB, a transcription factor that binds to the cAMP-responsive element, in mediating the AEF-stimulated SC proliferation and differentiation.
M M, Lee, C, Sato-Bigbee, G H, De Vries
openaire   +2 more sources

CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.

The Journal of Immunology, 1997
Abstract Cyclic AMP-responsive element binding protein (CREB) mediates gene expression in response to cAMP stimulation. The transcriptional activity of CREB depends on both the phosphorylation of Ser133 and the recruitment of cofactor for assembly of transcriptional complex.
Y P, Hsueh, H E, Liang, S Y, Ng, M Z, Lai   +3 more
openaire   +2 more sources

Transcriptional Regulation of CREB (Cyclic AMP Response Element‐Binding Protein) Expression in CATH.a Cells

Journal of Neurochemistry, 1996
Abstract: We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element‐binding protein (CREB) is down‐regulated in CATH.a cells (a neural‐derived cell line) by activation of the cAMP pathway. We now demonstrate that this down‐regulation can be accounted for by a decrease in the rate of CREB gene transcription.
K L, Widnell, J S, Chen, P A, Iredale, W H, Walker, R S, Duman, J F, Habener, E J, Nestler   +6 more
openaire   +2 more sources

5-hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and jun D as common components in cerebellar neurons

Neuroscience, 1999
Previous studies from our laboratory have demonstrated that stimulation of 5-hydroxytryptamine2A receptors in rat cerebellar granule cells produces an increase in the levels of 5-hydroxytryptamine2A receptor messenger RNA and binding sites, and that this up-regulation requires de novo RNA and protein synthesis.
E, Chalecka-Franaszek, H, Chen, D M, Chuang   +2 more
openaire   +2 more sources

Cyclic AMP Response Element Binding Protein (CREB) and CREB Binding Protein (CBP) in Global Cerebral Ischemia

Journal of Molecular Neuroscience, 2001
Cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that has been implicated in neuronal responses to ischemia. We examined the effect of global cerebral ischemia in the rat on the expression of CREB, its transcriptionally active phosphorylated form (pCREB), and the nuclear adaptor protein, CREB binding protein (CBP ...
K, Jin, X O, Mao, R P, Simon, D A, Greenberg   +3 more
openaire   +2 more sources

Identification of Cyclic AMP Response Element-Binding Protein-Dependent Transcriptional Responses in Hypoxia by Microarray Analysis

2004
Publisher Summary This chapter discusses identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis. A functional role for the cyclic AMP response element-binding protein (CREB) is demonstrated in controlling gene expression in hypoxia.
Martin O, Leonard, Susan, O'Reilly, Katrina M, Comerford, Cormac T, Taylor   +3 more
openaire   +2 more sources