Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor [PDF]
, 2016 The cyclic depsipeptide FK228 is the only natural product histone deacetylase (HDAC) inhibitor that has advanced to clinical trials as an anticancer agent.
Shijun Wen (1670017) +2 more
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Structure of New Cyclic Depsipeptides, Bu-2841-08 and -10
The Journal of Antibiotics, 1995 The structures of new antibiotics, Bu-2841-08 and -10, have been determined. They are cyclic depsipeptides and the sequence of amino acid residues was established by mass spectral analysis of the hydrolyzed linear peptide and NMR spectral analysis of the parent cyclic peptides.
T, Fukai +5 more
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Kulolide: A Cytotoxic Depsipeptide from a Cephalaspidean Mollusk, Philinopsis speciosa1 [PDF]
, 2016 Kulolide, a cyclic depsipeptide, was isolated from a cephalaspidean mollusk, Philinopsis speciosa Pease, 1860. Kulolide is made up of five amino acid residues, one each of l-Ala, l-Pro, and N-Me-d-Val and two of l-Val, and two carboxylic acids, l-3 ...
Stephen J. Coval (2998032) +6 more
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Bacterial Production of the Tunicate-Derived Antitumor Cyclic Depsipeptide Didemnin B [PDF]
, 2016 Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the development of these compounds is the problem of supply.
Sachiko Matsumoto (1777579) +8 more
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Data from: Total Synthesis of the Cyclic Depsipeptide YM-280193, a Platelet Aggregation Inhibitor [PDF]
Attached file provides supplementary data for linked article. The first total synthesis of YM-280193, a cyclic depsipeptide that inhibits the ADP-induced aggregation of human platelets, is described.
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Ecotoxicology and Environmental SafetyIn current study, Fusarium mycotoxin, beauvericin (BEA), has endocrine disrupting potential through suppressing the exogenous androgen receptor (AR)-mediated transcriptional activation.
Da-Hyun Jeong +3 more
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Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer. [PDF]
Angew Chem Int Ed Engl, 2020 Grab HA, Kirsch VC, Sieber SA, Bach T.
europepmc +1 more source
FIELD DESORPTION MASS-SPECTRA OF THE CYCLIC DEPSIPEPTIDE VALINOMYCIN - ENERGY DEFICITS IN ION FORMATION [PDF]
The formation of ions of the cyclic depsipeptide valinomycin by field desorption has been investigated in detail. The ratio of molecular ions M+. to protonated molecules [M + H]+ has been found to be independent of emitter heating current and the nature ...
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Isolation and structure determination of a new depsipeptide crocapeptin C from the myxobacterium Melittangium boletus [PDF]
A new cyclic depsipeptide, crocapeptin C (1), containing 3-amino-6-hydroxy-2-piperidone (Ahp) was isolated from the methanol extract of the myxobacterium Melittangium boletus. The chemical structure of crocapeptin C (1) was determined through NMR and ESI-
Chanaphat Thetsana (17845085) +3 more
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Plitidepsin: design, development, and potential place in therapy
Drug Design, Development and Therapy, 2017 Sara Alonso-Álvarez,1 Emilia Pardal,2 Diego Sánchez-Nieto,3 Miguel Navarro,4 Maria Dolores Caballero,1 Maria Victoria Mateos,1 Alejandro Martín1 1Hematology Department, IBSAL-CIC-USAL, Hospital Universitario de Salamanca, Salamanca,
Alonso-Álvarez S +6 more
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