Results 151 to 160 of about 3,681 (193)
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Synergistic action of a cyclic depsipeptide and piperazine on nematodes
Parasitology Research, 2000The present study describes the synergistic effects of the cyclic depsipeptide BAY 44-4400 and piperazine in the treatment against the nematodes Trichinella spiralis, Heligmosomoides polygyrus, and Heterakis spumosa. The in vitro anthelmintic activity of a combination of the two compounds (1.7 motility units) against T.
F, Nicolay +3 more
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Total synthesis of antimicrobial and antitumor cyclic depsipeptides
Chemical Communications, 2010The total synthesis of natural products "has to be viewed as an art and a science that needs to be advanced for its own sake" (K. C. Nicolaou) and indeed, the achievements within this field of chemistry during the last decades are astonishing. However, besides its inherent beauty, total synthesis also opens the gates widely to a better understanding of
Wenhua, Li +2 more
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A Total Synthesis of the Cyclic Depsipeptide Chaiyaphumine‐A
ChemistrySelect, 2017Abstract The first total synthesis of Chaiyaphumine‐A, a cyclic depsipentapeptide isolated from Xenorhabdus SP. PB614 which showed good activity against Plasmodium falcifarum (IC 50 = 0.61 μM ...
Somnath S. Gholap, Sandip R. Ugale
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Inhibition of Topoisomerase II by a Novel Antitumor Cyclic Depsipeptide, BE-22179 [PDF]
Japanese Journal of Cancer Research, 1994 BE‐22179, a novel cyclic depsipeptide antibiotic having two 3‐hydroxyquinoline moieties, inhibited the DNA‐relaxing activity of L1210 topoisomerase II completely at 0.08 μM. This effect was far stronger than that of VP‐16. However, it did not show any marked effect on topoisomerase II‐mediated DNA cleavage.
A Okura, T Yoshinari
exaly +3 more sources
Arthogalin, a Cyclic Depsipeptide from the Lichen Arthothelium galapagoense
Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 1995 The structure and stereochemistry of arthogalin from the liehen Arthothelium galapagoense has been elucidated as the cyclic depsipeptide 1′.
S Huneck
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Chemistry and Biology of Cyclic Depsipeptides of Medicinal and Biological Interest
Current Medicinal Chemistry, 2004Cyclodepsipeptides comprise a wide variety of cyclic peptides of natural origin and are characterized by the occurrence of at least one ester linkage. The great interest that this class of natural products has elicited in scientific community is explained by their wide range of biological activities, intriguing mechanisms of action and attractive ...
Francisco, Sarabia +4 more
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Cyclic Peptides and Depsipeptides from Fungi
2009This chapter describes the occurrence of cyclic peptides and cyclic depsipeptides within the kingdom Eumycota (true fungi), the diversity of structures and their chemical building blocks, their ecological roles and their different biological activities.
Heidrun Anke, Luis Antelo
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Total synthesis of an antifungal cyclic depsipeptide aureobasidin A
Tetrahedron, 1996Abstract The first total synthesis of antifungal cyclic depsipeptide aureobasidin A is described. The synthesis was achieved mainly using bromotris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) as a coupling reagent. Peptide cyclization was carried out between L- allo -isoleucine (L- a lle 1 ) and L- Pro 9 residues in the linear nonapeptide ...
Toru Kurome +6 more
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New Cyclic Depsipeptide from an Endophytic Actinomycete
Chemistry of Natural Compounds, 2015A new sixteen-member cyclic depsipeptide, strepeptolide, was isolated from the culture broth of an endophytic actinomycetes strain. The structure of the compound was elucidated by detailed 1D, 2D NMR, HR-ESI-MS, and IR spectroscopic data.
Yi Jiang, Lixing Zhao, Xueshi Huang
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Asymmetric Total Syntheses of Marine Cyclic Depsipeptide Halipeptins A–D
Chemistry – A European Journal, 2006AbstractHalipeptins A–D (1 a–d) are a family of natural cyclic depsipeptides isolated from marine sponges. Total syntheses of these four compounds are detailed in this report. The key elements in this synthesis include the elaboration of the polysubstituted decanoic acid parts by two asymmetric aldol reactions, assembly of the N‐methyl‐δ ...
Shouyun, Yu, Xianhua, Pan, Dawei, Ma
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