Results 131 to 140 of about 3,681 (193)

Anticancer efficacy of Spiruchostatin A: current insights into histone deacetylase inhibition and oncologic applications. [PDF]

Eur J Med Res
Ibrahim S, Khan MU, Khurram I, Ghani MU, Sharifi-Rad J, Calina D.   +5 more
europepmc   +1 more source

NRPS and PKS pathways in actinomycetes: A review of biosynthetic diversity and bioactive potential. [PDF]

Curr Res Pharmacol Drug Discov
Chauhan A, Gurnani M, Arora J, Chauhan R, Ranjan A, Chandra Joshi N, Dufossé L, Jindal T.   +7 more
europepmc   +1 more source

Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator. [PDF]

Mol Pharmacol
Do TQ, Blackwell DJ, Smith AN, Thorpe MP, Rebbeck RT, Laver DR, Johnston JN, Knollmann BC.   +7 more
europepmc   +1 more source

The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release. [PDF]

Mol Pharmacol
Issa NT, Shen T, Vizurraga A, Pronin A, Henry T, Wang Q, Kwarcinski FE, Schürer S, Badiavas E, Tall GG, Slepak VZ.   +10 more
europepmc   +1 more source

The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide. [PDF]

Chem Sci
Thorpe MP, Smith AN, Blackwell DJ, Hopkins CR, Knollmann BC, Akers WS, Johnston JN.   +6 more
europepmc   +1 more source

Ecological interactions drive metabolomic diversification in Amazonian <i>Pseudonocardia</i> symbionts. [PDF]

mSystems
Grundmann CO, Melo WGP, Caraballo Rodríguez AM, Guardia NUdA, Migliorini ILF, Da Silva RR, Dorrestein PC, Lopes NP, Currie CR, Clardy J, Pupo MT.   +10 more
europepmc   +1 more source

The investigation of immunomodulatory effects of didemnin B in macrophage cells. [PDF]

Immunol Res
Dağ HE, Atalay BR, Ayaz F, Ayaz EA, Deviren A.   +4 more
europepmc   +1 more source

A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides. [PDF]

J Am Chem Soc
Wall BJ, Chaudhury U, Sharma KK, Venditti V, VanVeller B.   +4 more
europepmc   +1 more source

Marine bioactive peptides with anticancer potential, a narrative review. [PDF]

Int J Biochem Mol Biol
Rafieezadeh D, Esfandyari G.
europepmc   +1 more source

Molecular insights into fungal inositol phosphorylceramide synthesis and its inhibition by antifungal aureobasidin A. [PDF]

Nat Commun
Chen J, Ke Y, Zhang M, Lin X, Hua Z, Zhang D, Hu X, Ding X, Li J, Yang P, Yu H.   +10 more
europepmc   +1 more source