Results 121 to 130 of about 10,177 (227)

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

Metabolites, 2015
There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to ...
Chandan Prasad, Victorine Imrhan, Shanil Juma, Mindy Maziarz, Anand Prasad, Casey Tiernan, Parakat Vijayagopal   +6 more
doaj   +1 more source

Bacterial Lipodepsipeptides and Some of Their Derivatives and Cyclic Dipeptides as Potential Agents for Biocontrol of Pathogenic Bacteria and Fungi of Agrarian Plants. [PDF]

J Agric Food Chem, 2022
Castaldi S, Cimmino A, Masi M, Evidente A.   +3 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

A Lavandula angustifolia flower extract and dipeptide‐4 blend modulates oxidative, glycative, autophagic and circadian pathways in human skin models

International Journal of Cosmetic Science, EarlyView.
The blend enhanced antioxidation, anti‐glycation, autophagy and circadian regulation in cell and skin models. Key markers included mitochondrial ROS, γ‐H2AX, AGEs, ATP, melatonin, LC3 and SOD. Significant improvements were visualized via fluorescence and quantified with statistical markers.
Lina Wang, Yuxuan Wu, Huiping Hu, Yanan Li, Peiwen Sun   +4 more
wiley   +1 more source

The PagDMG6341–PagWD40–PagPOLD4 Module Coordinates Base Excision Repair in ‘84K’ Poplar (Populus alba × P. glandulosa)

Plant Biotechnology Journal, EarlyView.
ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling, Yijia Jin, Yufei Xia, Shenxiu Jiang, Jianghai Shu, Xiaotong Hu, Kang Du, Pingdong Zhang, Xiangyang Kang   +8 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Novel 2,5-Diketopiperazines with In Vitro Activities against Protozoan Parasites of Tropical Diseases

Pharmaceuticals
Malaria, Chagas disease, and leishmaniasis are tropical diseases caused by protozoan parasites of the genera Plasmodium, Trypanosoma and Leishmania, respectively.
Isabela P. Ceravolo, Letícia F. Leoni, Antoniana U. Krettli, Silvane M. F. Murta, Daniela de M. Resende, Mariza G. F. de M. L. Cruz, Jodieh O. S. Varejão, Lorena L. Mendes, Eduardo V. V. Varejão, Markus Kohlhoff   +9 more
doaj   +1 more source

BITTER PEPTIDES, OCCURRENCE AND STRUCTURE [PDF]

, 2017
The bitter taste of many protein rich foods resides in the peptide fraction. 61 bitter tasting peptides, isolated from natural systems, and 145 bitter tasting synthetic peptides are reviewed.
GUIGOZ, Y., SOLMS, J.
core  

Pyrene‐Conjugated, 2‐Pyridinecarboxaldehyde Derivatives as N‐Terminus‐Specific Tags for MALDI‐ and LALDI‐MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li, Murat Kucukdisli, Florian Braun, David W. Will, Nadine Meier, Bettina Wehrle, Larissa Chiara Meyer, Melanie Christine Föll, Oliver Schilling   +8 more
wiley   +1 more source