Results 151 to 160 of about 10,177 (227)

Bacterial β-peptidyl aminopeptidases: on the hydrolytic degradation of β-peptides [PDF]

open access: yes, 2018
The special chemical and biological features of β-peptides have been investigated intensively during recent years. Many studies emphasize the restricted biodegradability and the high metabolic stability of this class of compounds.
Geueke, B., Kohler, H.-P
core  

Human Cyclophilins—An Emerging Class of Drug Targets

open access: yesMedicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova   +3 more
wiley   +1 more source

Publications of the exobiology program for 1983: A special bibliography [PDF]

open access: yes
A list of 1983 publications resulting from research pursued under the auspices of NASA's Exobiology Program is given. Topics in the fields of biological, chemical, and planetary evolution; geochemistry; and intelligent extraterrestrial life are ...
Devincenzi, D. L., Pleasant, L. G.
core   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

open access: yesNew Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov   +16 more
wiley   +1 more source

Effect of α‐Hydrazino Acids on the Performance of H‐Pro–Pro‐Xaa Catalysts in the Conjugate Addition of Aldehydes to Nitroolefins

open access: yesChemistrySelect, Volume 11, Issue 11, 18 March 2026.
The tripeptide Pro‐Pro‐D‐hVal‐OMe, which lacks an acidic group, catalysed the conjugate addition of aldehydes to nitroolefins and afforded γ‐nitroaldehydes in 79–97% yield and 88:14–93:7 e.r. The proposed reaction mechanism relies on the active role of hydrazide NHβ or NHα protons in hydrogen bonding with the reacting species.
Ivona Banović   +2 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

open access: yesSmall, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti   +5 more
wiley   +1 more source

Temporal Control Over Complex, Simple, and Multiphase Coacervates Using Ureolysis and Ammonium Carbonate Decomposition

open access: yesChemSystemsChem, Volume 8, Issue 2, March 2026.
A new strategy for temporal control over simple and complex coacervates is described here. The urea‐urease reaction results in the timed formation and/or destruction of complex coacervates after controllable delays. This strategy is easily adaptable to different time scales and polyelectrolyte pairs.
Shana Shirin Valapra   +4 more
wiley   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

open access: yesAllergy, Volume 81, Issue 3, Page 884-901, March 2026.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat   +16 more
wiley   +1 more source

Crystal structure of plant γ‐glutamyl peptidase 1: implications for sulfur metabolism and secondary metabolite biosynthesis

open access: yesThe FEBS Journal, Volume 293, Issue 5, Page 1400-1414, March 2026.
The crystal structures of Arabidopsis thaliana γ‐glutamyl peptidase 1 (GGP1), including the covalent intermediate state, were determined. GGP1 is involved in both glutathione degradation in the primary metabolism and glutathione conjugate processing in the secondary metabolism of glucosinolate and camalexin biosynthesis.
Kosei Sone   +7 more
wiley   +1 more source

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