Rational and combinatorial tailoring of bioactive cyclic dipeptides [PDF]
Frontiers in Microbiology, 2015 Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They display a broad variety of biological and pharmacological activities and have long been recognized as privileged structures with the ability to bind to a wide ...
Tobias Wolfgang Giessen +2 more
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Identification of Cyclic Dipeptides and a New Compound (6-(5-Hydroxy-6-methylheptyl)-5,6-dihydro-2H-pyran-2-one) Produced by Streptomyces fungicidicus against Alternaria solani [PDF]
Molecules, 2022 As an important microbial resource, Actinomycetes, especially Streptomyces, have important application values in medicine and biotechnology. Streptomyces fungicidicus SYH3 was isolated from soil samples in tomato-growing areas and showed good inhibitory ...
He Liu +11 more
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Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans [PDF]
Scientific ReportsGenistein and daidzein are isoflavonoid phytoalexins that increase rapidly during bean hypersensitive immunity to Pseudomonas savastanoi pv. phaseolicola. To understand how genistein and daidzein affect P. savastanoi pv.
Bret Cooper +2 more
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Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia Solanacearum [PDF]
Molecules, 2018 Ralstonia solanacearum is a causative agent of bacterial wilt in many important crops throughout the world. How to control bacterial wilt caused by R. solanacearum is a major problem in agriculture.
Shihao Song +7 more
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New Pyridinium Compound from Marine Sediment-Derived Bacterium Bacillus licheniformis S-1 [PDF]
MoleculesThe structural diversity of marine natural products is considered a potential resource for the pharmaceutical industry. In our study of marine-derived compounds, one bacterium Bacillus licheniformis S-1 was discovered to have the ability to produce ...
Han Wang +5 more
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Protein synthesis with conformationally constrained cyclic dipeptides. [PDF]
Bioorg Med Chem, 2020 We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lysine, having 5-, 6-, and 7-membered lactam rings, respectively.
Zhang C, Bai X, Dedkova LM, Hecht SM.
europepmc +4 more sources
The tRNA-dependent biosynthesis of modified cyclic dipeptides. [PDF]
Int J Mol Sci, 2014 In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnover and secondary metabolite assembly.
Giessen TW, Marahiel MA.
europepmc +4 more sources
Frontiers in Cell and Developmental Biology, 2022 Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA ...
Tomo Shiota +13 more
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Active site remodelling of a cyclodipeptide synthase redefines substrate scope
Communications Chemistry, 2022 Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates, however the substrate selection mechanism is not yet known.
Emmajay Sutherland +2 more
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Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials. [PDF]
Protein Pept Lett, 2020 Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cyclic dipeptides have been studied in
Chen Y +5 more
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