Results 51 to 60 of about 10,177 (227)

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Synthesis and Antimalarial Evaluation of Cyclic β-Amino Acid-Containing Dipeptides

Molecules, 2008
This paper describes an efficient synthesis and the antiparasitic evaluation ofcyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial propertiesof all these dipeptides have been evaluated in vitro against Plasmodium falciparum
M. P. Kaushik, A. K. Srivastava, D. Thavaselvam, Manisha Sathe   +3 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

An Update on 2,5-Diketopiperazines from Marine Organisms

Marine Drugs, 2014
2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms.
Ri-Ming Huang, Xiang-Xi Yi, Yuying Zhou, Xiangdong Su, Yan Peng, Cheng-Hai Gao   +5 more
doaj   +1 more source

Enhanced sampling of multidimensional free-energy landscapes using adaptive biasing forces

, 2010
We propose an adaptive biasing algorithm aimed at enhancing the sampling of multimodal measures by Langevin dynamics. The underlying idea consists in generalizing the standard adaptive biasing force method commonly used in conjunction with molecular ...
Chipot, Chris, Lelièvre, Tony
core   +3 more sources

Synthesis of new beta-amidodehydroaminobutyric acid derivatives and of new tyrosine derivatives using copper catalyzed C-N and C-O coupling reactions [PDF]

, 2012
Several beta-amidodehydroaminobutyric acid derivatives were prepared from N,C-diprotected beta-bromodehydroaminobutyric acids and amides by a copper catalyzed C-N coupling reaction.
Ferreira, Paula M. T., Pereira, Goreti, Vilaça, Helena   +2 more
core   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Computational approaches to understanding the self-assembly of peptide-based nanostructures [PDF]

, 2015
The interest in the self-assembly of peptide-based systems has grown significantly over the past 10–15 years, as more and more applications are shown to benefit from the useful properties of the amino acid based monomers.
Barz, Beke, Bellesia, Blanco-Canosa, Brooks, Cao, Carmichael, Case, Castelletto, Chapman, Chen, Colombo, Cornell, Cote, Debnath, der Spoel, Eckes, Engels, Engin, Felice, Filot, Fleming, Fleming, Frederix, Frederix, Garcia-Fandino, Gorbitz, Gorbitz, Gough, Grimme, Guo, Guo, Han, Heinz, Heinz, Heinz, Hirst, Hughes, Hughes, Jayawarna, Jorgensen, Jun, Khurana, Kim, Lee, Lee, Lee, Li, Liberato, Liu, Mackerell, MacKerell, Marchesan, Marchesan, Marchesan, Marchesan, Marchesan, Marrink, Matthes, Mayo, Mondal, Montenegro, Monticelli, Morris, Mu, Mu, Murase, Nowinski, Nuansing, Orbach, Pashuck, Ponder, Qu, Rauschenberg, Raz, Reches, Reches, Rymer, Scanlon, Schafer, Seo, Shin, Smith, So, Stendahl, Sun, Tamamis, Tanford, Tsai, Tsonchev, Tsonchev, Tuttle, Velichko, Vijayaraj, Villa, Villa, Wang, Weiner, Weiner, Williams, Xu, Xu, Yu, Yu, Zhang, Zhang, Zhao, Zhao, Zhao, Zou   +109 more
core   +1 more source

Biomimetic epoxidation in aqueous media catalyzed by cyclic dipeptides [PDF]

Synthetic Communications, 2016
We have developed a practical epoxidation of electron-deficient enones in aqueous media using cyclic dipeptides as bioinspired green catalyst. Optimizing the reaction conditions in a triphasic system led to efficient conditions providing epoxides with good enantioselectivities.
Bérubé, Christopher, Voyer, Normand
openaire   +1 more source