Results 151 to 160 of about 611,110 (302)

The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation. [PDF]

J Biol Chem, 2023
Bhattacharya M, Bhowmik D, Tian Y, He H, Zhu F, Yin Q.   +5 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cyclic GMP suppresses most of the cyclic AMP-induced stimulation of new RNA synthesis in primary rat hepatocytes

, 1975
Cyclic GMP suppresses most of the cyclic AMP-induced stimulation of new RNA synthesis in primary rat hepatocytes in ...
E. DRAGHI, P. G. ANDREIS, ARMATO, Ubaldo
core   +1 more source

Targeting the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway: An Emerging Therapeutic Strategy for Digestive Diseases. [PDF]

Clin Transl Gastroenterol
Fang Y, Wang R, Du X, Ying Z, Yang Y, Yang Y, Cheng Y, Pan Z, Lu X, Zhou J.   +9 more
europepmc   +1 more source

Cyclic GMP and PKG Signaling in Heart Failure. [PDF]

Front Pharmacol, 2022
Numata G, Takimoto E.
europepmc   +1 more source

Physics‐Based Encoder‐Only Transformer for Structural Hysteresis Prediction and Dynamic Analysis

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Accurate modeling of structural hysteresis is a critical task for ensuring the safety of structures through reliable response predictions. However, conventional hysteresis models often struggle to represent diverse hysteresis characteristics observed in real‐world structures, as the manual selection of a model form may not assure validity and ...
Jongha Joo, Jaehwan Jeon, Junho Song
wiley   +1 more source

Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress. [PDF]

Hepatol Commun
Babuta M, Datta AA, de Carvalho Ribeiro M, Santos BACD, Morel C, Copeland C, Ortega-Ribera M, Mehta J, Calenda C, Wang Y, Remotti V, Brezani V, Patel A, Hawryluk D, Szabo G.   +14 more
europepmc   +1 more source

Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation. [PDF]

Int J Mol Sci, 2023
Ma X, Iyer SR, Ma X, Reginauld SH, Chen Y, Pan S, Zheng Y, Moroni DG, Yu Y, Zhang L, Cannone V, Chen HH, Ferrario CM, Sangaralingham SJ, Burnett JC.   +14 more
europepmc   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Fulfilling the Promise of Cyclic GMP Signaling in Heart Failure With Reduced Ejection Fraction. [PDF]

JACC Heart Fail
Reddy YNV.
europepmc   +1 more source