Results 161 to 170 of about 611,110 (302)

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases. [PDF]

Sci Immunol, 2023
Mosallanejad K, Kennedy SN, Bahleda KM, Slavik KM, Zhou W, Govande AA, Hancks DC, Kranzusch PJ, Kagan JC.   +8 more
europepmc   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

Cyclic GMP-dependent activation of Ca²⁺ release from the ER and digestive vacuole at distinct phases of intraerythrocytic Plasmodium falciparum development. [PDF]

J Biol Chem
Singh MK, Honorio RI, Bartlett PJ, Garcia CRS, Thomas AP.   +4 more
europepmc   +1 more source

Cyclic GMP and neurone death [PDF]

Nature, 1985
openaire   +2 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Pseudorabies virus tegument protein pUL49 antagonizes cyclic GMP-AMP synthase through phase separation to promote viral replication. [PDF]

Front Microbiol
Gan L, Gao Y, Ma L, Zhang Y, Chai S, Li H, Zhang M, Yang X, Xiao Q, Xie Y, Zhao L, Sun P, Li Z.   +12 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Pathophysiological and therapeutic implications of C-type natriuretic peptide/cyclic GMP signaling in pulmonary fibrosis. [PDF]

JCI Insight
Weyer R, Völker K, Potapenko T, Krebes L, Abeßer M, Friedrich AL, Lessmann E, Khadim A, Ruppert C, El Agha E, Sheta D, Beilhack A, Santi DV, Schneider EL, Kuhn M, Dabral S.   +15 more
europepmc   +1 more source

Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. [PDF]

Cardiovasc Res, 2022
Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC, Hobbs AJ, Schmidt HHHW.   +9 more
europepmc   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source