Results 181 to 190 of about 611,110 (302)

The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy. [PDF]

J Virol, 2022
Jiang S, Xia N, Luo J, Zhang Y, Cao Q, Zhang J, Wang Y, Zhao Y, Zheng W, Chen N, Meurens F, Li X, Zhu J.   +12 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Melatonin alleviates neuroinflammation in ischemic stroke by regulating cyclic GMP-AMP synthase- mediated microglial pyroptosis signaling. [PDF]

Neural Regen Res
Li Q, Feng L, Tian Y, Guo E, Li Y, Niu J, Pan H, Dang C, Lu Y, Wang L.   +9 more
europepmc   +1 more source

High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Metabolic Disorders via the Cyclic GMP-AMP Synthase-Stimulator of Interferon Gene Signaling Pathway. [PDF]

Int J Mol Sci, 2023
Hu Z, Li X, Yang Y, Zhang Z, Ding S.
europepmc   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

Less Severe Inflammation in Cyclic GMP-AMP Synthase (cGAS)-Deficient Mice with Rabies, Impact of Mitochondrial Injury, and Gut-Brain Axis. [PDF]

Biology (Basel)
Areekul P, Bhunyakarnjanarat T, Suebnuson S, Somsri K, Trakultritrung S, Taveethavornsawat K, Tencomnao T, Boonyasuppayakorn S, Leelahavanichkul A.   +8 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment. [PDF]

PeerJ
Zin Myint HN, Saranaruk P, Paungpan N, Waraasawapati S, Pairojkul C, Saisomboon S, Settha N, Pattanachot J, Okada S, Seubwai W, Kitkhuandee A, Sawanyawisuth K, Vaeteewoottacharn K.   +12 more
europepmc   +1 more source

A Bioengineered In Vitro Model to Assess AAV-Based Gene Therapies for Cyclic GMP-Related Disorders. [PDF]

Int J Mol Sci, 2022
Pavlou M, Babutzka S, Michalakis S.
europepmc   +1 more source