Results 181 to 190 of about 43,561 (311)

Fulfilling the Promise of Cyclic GMP Signaling in Heart Failure With Reduced Ejection Fraction. [PDF]

JACC Heart Fail
Reddy YNV.
europepmc   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Pathophysiological and therapeutic implications of C-type natriuretic peptide/cyclic GMP signaling in pulmonary fibrosis. [PDF]

JCI Insight
Weyer R, Völker K, Potapenko T, Krebes L, Abeßer M, Friedrich AL, Lessmann E, Khadim A, Ruppert C, El Agha E, Sheta D, Beilhack A, Santi DV, Schneider EL, Kuhn M, Dabral S.   +15 more
europepmc   +1 more source

Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. [PDF]

Cardiovasc Res, 2022
Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC, Hobbs AJ, Schmidt HHHW.   +9 more
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Bridging innate immunity and iron-dependent death: the interplay between cyclic GMP-AMP synthase-stimulator of interferon genes nexus and ferroptosis in cancer and inflammation. [PDF]

Front Cell Dev Biol
Chen XX, Hou YQ, Chen XX, Zhou Q, Wang X.   +4 more
europepmc   +1 more source

Cyclic GMP-AMP Synthase (cGAS) Deletion Reduces Severity in Bilateral Nephrectomy Mice through Changes in Neutrophil Extracellular Traps and Mitochondrial Respiration. [PDF]

Biomedicines, 2023
Suksawad N, Udompornpitak K, Thawinpipat N, Korwattanamongkol P, Visitchanakun P, Phuengmaung P, Saisorn W, Kueanjinda P, Leelahavanichkul A.   +8 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP. [PDF]

Sci Adv
Ali M, Dura R, Guery MA, Colard-Itté E, Cheviet T, Robresco L, Berry L, Lionne C, Lavazec C, Claessens A, Peyrottes S, Wengelnik K, Wein S, Cerdan R.   +13 more
europepmc   +1 more source

Cyclic GMP in Liver Cirrhosis-Role in Pathophysiology of Portal Hypertension and Therapeutic Implications. [PDF]

Int J Mol Sci, 2021
Kreisel W, Lazaro A, Trebicka J, Grosse Perdekamp M, Schmitt-Graeff A, Deibert P.   +5 more
europepmc   +1 more source