Results 201 to 210 of about 36,678 (264)

What Is the Acheulean?

Evolutionary Anthropology: Issues, News, and Reviews, Volume 35, Issue 2, June 2026.
ABSTRACT The Acheulean represents the longest cultural period known to human history, lasting globally for more than 1.75 million years. It may have emerged as early as 1.95 Ma in Africa, spreading throughout much of the continent and then into Eurasia and lasting up to 350–200 ka in western Europe and South Asia, and even later in eastern Asia ...
Marie‐Helene Moncel, Carolina Cucart‐Mora, Marta Arzarello, Nick Ashton, Javier Baena, Deborah Barsky, Ignacio de la Torre, Nena Galanidou, Paula García‐Medrano, Christine Hertler, Gadi Herzlinger, Thomas Ingicco, Hao Li, Dongdong Ma, Marina Mosquera, Andreu Ollé, Shanti Pappu, Shuwen Pei, Chun Tian, Wei Wang, Christopher J. Bae   +20 more
wiley   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS‐STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

Glia, Volume 74, Issue 6, June 2026.
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Esma I. Yerlikaya, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Clay T. Yeager, Kashif A. Shaikh, Edward W. Harhaj, Alistair J. Barber, Michael D. Dennis   +8 more
wiley   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

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Cyclic GMP and Cell Movement

Nature, 1973
THE movement of mammalian cells can be inhibited by agents which mimic or produce increases in the intracellular levels of cyclic 3′,5′-adenosine monophosphate (cyclic AMP)1,2. Goldberg and coworkers3,4 have proposed that in a number of cell types cyclic 3′,5′-guanosine monophosphate (cyclic GMP) promotes cellular events that are antagonistic to those ...
R D, Estensen, H R, Hill, P G, Quie, N, Gogan, N D, Goldberg   +4 more
openaire   +4 more sources

Cyclic GMP transporters

Neurochemistry International, 2004
The biokinetics of guanosine 3',5'-cyclic monophosphate (cGMP) is characterized by three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged cGMP by transport proteins in the cell membrane.
openaire   +2 more sources

Cyclic GMP-Hydrolyzing Phosphodiesterases

2009
The cyclic nucleotides (cN), cAMP and cGMP, are key second messengers that mediate the intracellular effects of many signals known as “first messengers”, including environmental signals such as photons for vision and chemicals for taste, as well as hormones, paracrine factors, neurotransmitters, or autocrine factors.
Sharron H, Francis, Jackie D, Corbin, Erwin, Bischoff   +2 more
openaire   +2 more sources

Cyclic AMP and cyclic GMP in hyperresponsiveness

Life Sciences, 1988
Cyclic-AMP has been shown to cause a hyperresponse in blood pressure change in conjunction with norepinephrine in the anesthetized rat system. Recent experiments show that the antagonist to angiotensin II, Sar1-Thr8 angiotensin II, abolishes the hyperresponse produced by c-AMP.
H T, Miller, W, Yesus, T, Cooper, S, Harwell   +3 more
openaire   +2 more sources

Intracellular cyclic GMP receptor proteins

The FASEB Journal, 1993
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP‐dependent protein kinases, cGMP‐regulated ion channels, and cGMP‐regulated cyclic nucleotide phosphodiesterases.
T M, Lincoln, T L, Cornwell
openaire   +2 more sources

Cyclic GMP signaling in podocytes

Microscopy Research and Technique, 2002
AbstractNatriuretic peptides (NP), together with nitric oxide (NO) are powerful relaxing factors acting via a common second messenger, cyclic GMP (cGMP). Together with other vasoactive modulators, these vasorelaxing factors play an essential role in regulating the function of kidney glomeruli.
Barbara, Lewko, Jan, Stepinski
openaire   +2 more sources