British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Auto/Paracrine C-Type Natriuretic Peptide/Cyclic GMP Signaling Prevents Endothelial Dysfunction. [PDF]
Int J Mol SciWerner F +12 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source
Brain endothelial cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway in aging and neurodegeneration. [PDF]
Neural Regen ResSun B, Li L, Luo J.
europepmc +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Connexin 43 Deficiency Confers Resistance to Immunotherapy in Lung Cancer via Inhibition of the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway. [PDF]
J Cell Mol MedZhang Y +9 more
europepmc +1 more source
Intestinal STING‐(Over)activation—A Contributing Factor to Food Allergies?
Allergy, EarlyView.
Sophie Goebel, Hannah Ruth Schiller
wiley +1 more source
2D Piecewise Linear Scalar Fields with Invertible Integral Lines
Computer Graphics Forum, EarlyView.Abstract Integral lines of the gradient flow are standard features in continuously differentiable scalar fields that enjoy some useful properties: They cover the domain densely, do not split, merge, or intersect, and are therefore invertible. For widely used discretizations of scalar fields, the corresponding polygonal approximations of integral lines ...
T.L. Erxleben +3 more
wiley +1 more source
Correlates of Plasma NT-proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial. [PDF]
J Am Heart AssocChiu L +11 more
europepmc +1 more source