Results 211 to 220 of about 450,778 (258)
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Interaction of caspase‐3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)
European Journal of Biochemistry, 2003Here, we show that recombinant bovine PDE5A1 is proteolysed by recombinant caspase‐3 in in vitro and transfected Cos‐7 cells. In addition, the treatment of PDE5A1‐transfected Cos‐7 and PC12 cells with staurosporine, an apoptotic agent that activates endogenous caspase‐3, also induced proteolysis and inactivation of PDE5A1.
Frame, Mhairi J +6 more
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Annual Review of Neuroscience, 1986
Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Cyclic GMP is central to visual excitation in vertebrate retinal rod cells. Sodium channels in the plasma membrane of the outer segment are kept open in the dark by a high level of cGMP. Light closes these channels by activating an enzymatic cascade that leads to the rapid hydrolysis of cGMP. Photoexcited rhodopsin triggers transducin by catalyzing the
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Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis
1994Several of the different PDE isozyme families have the ability in vitro to hydrolyze cGMP. In particular they include the CaM-dependent PDEs, the cGMP-stimulated PDEs, and the cGMP binding, cGMP-specific PDEs. Existing evidence suggests or demonstrates that in different cell types, each of these can be important determinants for the control of cGMP ...
W K, Sonnenburg, J A, Beavo
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Effect of Cyclic GMP on Intestinal Transport
1994Publisher Summary Cyclic guanosine monophosphate (cGMP) was established as an important regulator of intestinal ion transport in the late seventies, when it was shown to be the intracellular mediator of salt and water secretion induced by Escherichia coli heat-stable enterotoxin (STa).
Vaandrager, A B, De Jonge, H R
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Separation of Cyclic GMP and Cyclic AMP
Analytical Biochemistry, 1996S, Villegas, L L, Brunton
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1978
This article examines some of the evidence for or against the hypothesis that guanosine 3′,5′-cyelic monophosphate (cGMP) is the intracellular mediator of the actions of acetylcholine (ACh), with particular emphasis on the situation in the mammalian nervous system.
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This article examines some of the evidence for or against the hypothesis that guanosine 3′,5′-cyelic monophosphate (cGMP) is the intracellular mediator of the actions of acetylcholine (ACh), with particular emphasis on the situation in the mammalian nervous system.
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THE FORMATION AND METABOLISM OF CYCLIC GMP*
Annals of the New York Academy of Sciences, 1971J G, Hardman +5 more
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Mechanisms of Cyclic-di-GMP Signaling in Bacteria
Annual Review of Genetics, 2006Urs Jenal, Jacob G Malone
exaly
Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function
Circulation Research, 2003Karin E. Bornfeldt +2 more
exaly