Results 191 to 200 of about 43,561 (311)

New photoactivatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations

, 1984
The cyclic nucleotides cyclic AMP and cyclic GMP are important intracellular messengers mediating the responses to neurotransmitters and neurohormones and regulating cellular function over a wide range of time scales. Despite the widespread acceptance of
Nerbonne, Jeanne M., Nargeot, Joel, Lester, Henry A., Richard, Sylvain   +3 more
core  

Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
Bradley McDaniels, Gregory M. Pontone, Kuhan Pushparatnam, Indu Subramanian   +3 more
wiley   +1 more source

The radiotherapy induced cyclic GMP-AMP-synthase re-localization and immune signature predicts HNSCC treatment efficacy. [PDF]

Commun Med (Lond)
Mekers VE, Span PN, Looman M, van den Bogaard L, Kho V, Melchers WJG, Bussink J, Kaanders JHAM, Ansems M, Adema GJ.   +9 more
europepmc   +1 more source

Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities. [PDF]

Front Endocrinol (Lausanne), 2022
Prasad H, Mathew JKK, Visweswariah SS.
europepmc   +1 more source

Cyclic GMP in the pig vitreous and retina after experimental retinal detachment

, 2008
Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Heij, E.C., La, La Heij, Ellen C, Diederen, R., Diederen, Roselie M H, Lemmens, Marijke A M, de Vente, Jan, De Vente, J., La Heij, E.C., Lemmens, M.A.M., Kijlstra, Aize, Vente, J., De, Hendrikse, F., Hendrikse, Fred, Kijlstra, A.   +13 more
core  

Clinical Outcome Assessments for Functional Performance in Spastic Paresis: Systematic Review, Critique, and Recommendations

Movement Disorders, EarlyView.
Abstract Background Spastic paresis, resulting from central nervous system lesions, significantly impairs functional performance. In the framework of the International Classification of Functioning, Disability, and Health, functional performance was defined as functioning at the activity level in relation to the impairment of body functions and ...
Martina Hoskovcova, Marjolaine Baude, Bo Biering‐Sørensen, Ota Gal, Mary P Galea, Jean‐Michel Gracies, Carmen Rodriguez‐Blazquez, Theodore Wein, Michelle Hyczy de Siqueira Tosin, Álvaro Sánchez‐Ferro, Tiago A Mestre, Matej Skorvanek, Robert Jech, The members of the MDS Clinical Outcome Assessments Scientific Evaluation Committee and MDS Spasticity Study Group   +13 more
wiley   +1 more source

Association of elevated cyclic GMP levels with hemodynamic changes in HFrEF patients treated with sacubitril/valsartan and vericiguat: a pilot study. [PDF]

Int J Cardiol Heart Vasc
Inoue T, Takahama H, Suzuki H, Arai M, Kikuchi N, Satoh T, Yaoita N, Yamamoto S, Nochioka K, Nakano M, Tatebe S, Takahashi J, Minamino N, Yasuda S.   +13 more
europepmc   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source

Less Severe Inflammation in Cyclic GMP-AMP Synthase (cGAS)-Deficient Mice with Rabies, Impact of Mitochondrial Injury, and Gut-Brain Axis. [PDF]

Biology (Basel)
Areekul P, Bhunyakarnjanarat T, Suebnuson S, Somsri K, Trakultritrung S, Taveethavornsawat K, Tencomnao T, Boonyasuppayakorn S, Leelahavanichkul A.   +8 more
europepmc   +1 more source

High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Metabolic Disorders via the Cyclic GMP-AMP Synthase-Stimulator of Interferon Gene Signaling Pathway. [PDF]

Int J Mol Sci, 2023
Hu Z, Li X, Yang Y, Zhang Z, Ding S.
europepmc   +1 more source