Results 151 to 160 of about 62,432 (257)

The nitric oxide-cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus. [PDF]

Physiol Rep, 2021
Okuyama E, Kawatani M, Hashimoto J, Tanimoto K, Hashimoto M, Matsumoto-Miyai K.   +5 more
europepmc   +1 more source

Sildenafil helps the beat go on

Experimental Physiology, EarlyView.
Jules C. Hancox
wiley   +1 more source

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A. Murray, Mikhael Bechelany, Ahmed Barhoum   +7 more
wiley   +1 more source

Decreased Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Impairs Angiogenesis in a Lamb Model of Persistent Pulmonary Hypertension of the Newborn. [PDF]

Am J Respir Cell Mol Biol, 2021
Sharma M, Rana U, Joshi C, Michalkiewicz T, Afolayan A, Parchur A, Joshi A, Teng RJ, Konduri GG.   +8 more
europepmc   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Transmembrane transport of the nucleotides cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) is challenging, but can be achieved using a two‐component system consisting of a synthetic anionophore (e.g., squaramides) and a lipophilic thymine derivative.
Uththara M.C. Rathnaweera, Olivia Sam, Karolis Norvaisa, Sarah R. Marshall, Randima D. De Silva Weerakonda Arachchige, Matúš Chvojka, Hennie Valkenier, Nathalie Busschaert   +7 more
wiley   +2 more sources

Hirudin promotes proliferation and osteogenic differentiation of HBMSCs via activation of cyclic guanosine monophosphate (cGMP)/protein kinase-G (PKG) signaling pathway. [PDF]

Bioengineered, 2022
Cao S, Li X, Feng T, Li Y, Ding H, Xie L, Yang Q.   +6 more
europepmc   +1 more source

Comparative efficacy of combination therapy including regenerative therapies versus monotherapy for erectile dysfunction: A systematic review and meta‐analysis

Andrology, Volume 14, Issue 2, Page 358-367, February 2026.
Abstract Background and objective The Current European Association of Urology guidelines do not provide recommendation for combination of regenerative therapies with standard therapies for erectile dysfunction. The aim of this study was to compare the efficacy of combined regenerative therapy with monotherapy for erectile dysfunction.
Alberto Quistini, Giuseppe Fallara, Marco Tozzi, Massimiliano Depalma, Rocco Damiano, Alessandro Palmieri, Fabio Castiglione, Andrea Salonia, Roberto Bianchi, Matteo Ferro, Asif Muneer, Hussain M. Alnajjar, Karl H. Pang   +12 more
wiley   +1 more source

Cyclic guanosine monophosphate and 10-year change in left ventricular mass: the Multi-Ethnic Study of Atherosclerosis (MESA). [PDF]

Biomarkers, 2021
Subramanya V, Zhao D, Ouyang P, Ying W, Vaidya D, Ndumele CE, Lima JA, Guallar E, Hoogeveen RC, Shah SJ, Heckbert SR, Kass DA, Post WS, Michos ED.   +13 more
europepmc   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source