Results 151 to 160 of about 84,969 (338)

The Cardiorenal Effects of Piper amalago Are Mediated by the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway and the Voltage-Dependent Potassium Channels. [PDF]

Pharmaceuticals (Basel), 2023
Monteiro LM, Klider LM, Marques AAM, Farago PV, Emiliano J, Souza RIC, Dos Santos AC, Dos Santos VLP, Wang M, Cassemiro NS, Silva DB, Khan IA, Gasparotto Junior A, Manfron J.   +13 more
europepmc   +1 more source

215 GUANOSINE 3′: 5′- CYCLIC MONOPHOSPHATE (cGMP) IN BROWN ADIPOSE TISSUE OF DEVELOPING RATS [PDF]

, 1978
Josef P. Skála, Peter Hahn, Brian L. Knight   +2 more
openalex   +1 more source

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study

ACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Objective There is an unmet need for safe and effective oral treatments for cutaneous lupus erythematosus (CLE). Afimetoran is an investigational, first‐in‐class, orally bioavailable, selective small molecule inhibitor of Toll‐like receptors (TLRs) 7 and 8.
Fareeda Hosein, Stanislav Ignatenko, Kristina D. Chadwick, Lin Zhu, Frédéric Baribaud, Jasmine Saini, Thanh Bach, Urvi Aras, WanYing Zhang, Hazem Karabeber, Michelle Dawes, Melanie Harrison, Leonidas N. Carayannopoulos, Gopal Krishna   +13 more
wiley   +1 more source

The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy. [PDF]

Front Immunol, 2023
Chen R, Liu M, Jiang Q, Meng X, Wei J.
europepmc   +1 more source

Characterisation of a Binary Transition Metal Complex of a 3ʹ,5ʹ-Cyclic Nucleotide [1]. Preparation and Structure of a Nickel(II) Complex of Guanosine 3ʹ,5ʹ-Cyclic Monophosphate [PDF]

, 1982
William S. Sheldrick
openalex   +1 more source

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang, Zhengren Xu, Wei Wang, Haihua Xiao, Zhiqiang Lin, Hongbin Han   +14 more
wiley   +1 more source

Nitric Oxide Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase Expression and Its Own Production Through the cGMP Signaling Pathway in Murine Microglia BV-2 Cells

Journal of Pharmacological Sciences, 2010
The present study examined the effect of the nitric oxide (NO) donor NOC18 on lipopolysaccharide (LPS)-induced NO production to investigate a regulation mechanism of NO production by microglial cells.
Yasuhiro Yoshioka, Nobuo Takeda, Akiko Yamamuro, Atsushi Kasai, Sadaaki Maeda   +4 more
doaj  

Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]

, 1998
Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core  

An Aqueous‐Compatible On‐Column Approach for the Conjugation of Nucleic Acids Using Amino Modifiers

Current Protocols, Volume 5, Issue 7, July 2025.
Abstract Nucleic acid conjugation has emerged as a powerful strategy for enhancing the chemical and biological versatility of synthetic oligonucleotides. Solid‐support synthesis of oligonucleotides provides an avenue for nucleic acid conjugation, so long as the method is inherently compatible with the synthesis cycle.
Jagandeep S. Saraya, Derek K. O'Flaherty
wiley   +1 more source

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia-Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate. [PDF]

Front Physiol, 2022
Kuzmiszyn AK, Selli AL, Smaglyukova N, Kondratiev T, Fuskevåg OM, Lyså RA, Ravna AW, Tveita T, Sager G, Dietrichs ES.   +9 more
europepmc   +1 more source